L. Liu

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

This paper introduces a pseudovirus system for deep mutational scanning of SARS-CoV-2 spike protein mutations, showing how they affect antibody neutralization and infection.

This study identifies LINC01184 as a tumor-promotive factor in hepatocellular carcinoma, showing its overexpression correlates with poor patient outcomes and its role in promoting cell proliferation and migration.

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

This study evaluates the combined developmental toxicity of cyhalofop-butyl and quizalofop-p-ethyl on zebrafish embryos, finding an antagonistic effect and altered gene expression related to apoptosis and cardiac development.

The paper introduces the JGI Plant Gene Atlas, a resource that improves gene function annotations by analyzing transcript abundance across 18 species and 604 tissues, identifying 64,620 genes with unknown functions.

The paper structures and characterizes Lassa virus glycoproteins from multiple lineages and identifies neutralizing antibodies that target conserved epitopes.

This study shows RGA1 improves pollen tube growth under low-light by enhancing sugar and energy metabolism in rice pistils.

This study identifies LINC02428 as a liver-specific lncRNA that suppresses hepatocellular carcinoma progression by inhibiting cell proliferation, migration, and inducing apoptosis.

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

The paper constructs a gene regulatory network in Arabidopsis to identify TFs regulating root-specific lincRNAs, revealing key regulators and their associated lincRNAs linked to root development.

This study evaluates the neutralization resistance of SARS-CoV-2 Omicron subvariants BA.4.6, BA.4.7, and BA.5.9 to antibodies, finding increased resistance to certain monoclonal antibodies and vaccine-induced sera.

The study investigates how ICOS/ICOSL signaling regulates macrophage polarization and IL-33's role in liver fibrosis progression in mice with schistosomiasis.

The paper shows that nuclear positioning before asymmetric division is essential for correct division plane specification in maize stomatal development.

This study derives a theoretical framework for co-segregation probability from genome architecture mapping and shows that normalization with many nuclear slices improves correlation with inter-locus distances.

This paper introduces CP-seq, a method to test thousands of drug combinations on single cells using microwell-based droplet random pairing and single-cell RNA sequencing.

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

This study characterizes the antigenic properties of the SARS-CoV-2 Omicron subvariant BA.2.75, showing increased neutralization resistance to vaccinated sera and specific monoclonal antibodies.

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

The paper identifies a DPP4 homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness, showing it is inhibited by diabetes drugs.

This study identifies βγ-CAT as a pore-forming protein that enables cells to scavenge extracellular proteins under starvation by promoting nutrient uptake and survival.

This study shows that asparagine restriction induces a biphasic response in CD8 T cells, enhancing their metabolic fitness and antitumoral function through ATF4/NRF2-dependent mechanisms.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.