L. Wang

This paper develops and validates prime editing vectors for plants, enabling large insertions and fluorescent tagging in dicots and monocots.

This study shows heparan sulfate aids SARS-CoV-2 entry and identifies drugs that inhibit this process in vitro.

The paper performs pan-genome analysis of peach and its wild relatives to identify genetic variations related to disease resistance and high-altitude adaptation.

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

This study shows that enhanced RNA-directed DNA methylation (RdDM) in reproductive organs increases DNA methylation, ensuring sexual reproduction in rice by regulating gene expression.

This study evaluates the accuracy of predicting compound selectivity using free energy calculations for kinase inhibitors, finding that systematic errors correlate between targets and longer simulations improve selectivity prediction.

This study identifies METTL4 as the methyltransferase responsible for m6A methylation of U2 snRNA in Drosophila, confirming its enzymatic activity in vitro and in vivo.

This study examines the correlation between anti-SARS-CoV-2 antibodies and molecular testing in different patient cohorts to assess their utility in patient triaging.

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

This study shows that early IL-6 neutralization with an anti-IL-6 mAb improves outcomes in Ebola-infected mice, suggesting potential benefits for treating cytokine release syndrome.

This paper describes a saliva-based SARS-CoV-2 testing method that avoids RNA extraction, achieving a detection limit comparable to nasal swabs and showing good performance with clinical samples.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This paper develops a nanoparticle platform for displaying trimeric antigens, showing that SARS-CoV-2 spike-LuS nanoparticles induce 25-fold higher neutralizing responses than spike alone.

This study investigates adaptive evolution of piRNA pathway proteins in Drosophila and finds that their evolution is driven by avoiding genomic auto-immunity rather than enhancing TE silencing.

This paper describes the development of an mRNA vaccine (mRNA-1273) against SARS-CoV-2, showing it induces neutralizing antibodies and CD8 T cell responses and protects mice from infection.

This study identifies annexin A2 as a target protein of chlorogenic acid in A549 cells, showing it inhibits tumor proliferation by suppressing NF-κB downstream anti-apoptotic genes.

The paper investigates the ability of Arhopalus rusticus to transmit pine wood nematodes, finding that 12 beetles can transmit the nematodes through feeding on pine needles.

The paper uses molecular markers and ecological niche models to study introgression between Betula tianshanica and Betula microphylla, finding bidirectional gene flow with implications for conservation.

This study shows cancer cells use fructose metabolism to drive the Warburg effect by converting glucose to fructose via polyol pathways and exporting fructose to the tumor microenvironment.

The paper shows that cell clusters can migrate in a collective amoeboid mode without adhesion, relying on supracellular contractility rather than traction forces.

This study examines the relationship between phosphorus digestibility and gut microbiota in goats, finding significant correlations between TDP and specific bacterial taxa in different gastrointestinal regions.

This study investigates the cardiac electrophysiological effects of hydroxychloroquine and azithromycin, showing they prolong QT intervals and increase arrhythmia risk when combined.

This study shows that Bcl6 deletion in Treg cells reduces tumor growth by impairing their suppressive function, and increased Bcl6 expression is linked to poor cancer outcomes.

The paper develops gene expression classifiers from nasal brush samples to predict RSV disease severity in infants, finding strong correlations with clinical scores.

This study compares two IDO1 inhibitors, showing GSK5628 selectively inhibits apo-IDO1 by competing with heme, while epacadostat binds to the heme cofactor, leading to longer-lasting inhibition.

The paper introduces a method to improve pathogen detection in metagenomic data by correcting abundance estimates using species-specific genomic regions, enhancing sensitivity and specificity for low-abundance pathogens.

The paper shows that IMD/Relish suppresses perilipin1, leading to lipid droplet enlargement that reduces ROS stress during bacterial infection in Drosophila.

This study identifies how neurosteroids interact with three distinct sites on the GABAA receptor, influencing activation and desensitization, and shows that site-specific binding determines their functional effects.

The paper shows that nutrient-growth dysregulation in yeast leads to the evolution of a metabolic defect involving organosulfur release, which confers a fitness advantage under specific conditions.

This study shows that STAT2 signaling both restricts SARS-CoV-2 spread and causes severe pneumonia in infected hamsters.