L. Wang

This study demonstrates that targeted enzyme replacement therapy using antibody-enzyme fusion proteins improves skeletal muscle phenotypes in Pompe disease mice compared to standard enzyme replacement therapy.

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.

This study examines microbiome recovery in Zostera marina after transplantation, finding that microbial communities recover within 14 days and correlate with plant morphology.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

The paper shows that ribosome stalling and phase separation are critical for transposon RNA processing and epigenetic silencing in plants.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

This paper proposes a two-stage deep learning method for ECG denoising using U-net and DR-net models, showing improved performance over single-stage methods.

The paper develops a sandwich ELISA method using monoclonal antibodies to detect pre-proinsulin in recombinant human insulin production.

The paper characterizes a novel EBV strain, Yu103, associated with both nasopharyngeal carcinoma and B-cell lymphoma, showing its dual tropism and unique genomic features.

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.

The paper identifies CDK8 as a negative regulator of STAT3 transcriptional activity in Th-1 cells, showing it limits STAT3's resident time at gene loci, thereby modulating IL-6 responses.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.

This study observes how lipofuscin is transported and removed from mouse myocardium using transmission electron microscopy.

This study develops an AI system to identify fetal nucleated red blood cells using deep learning, achieving high accuracy and sensitivity in testing.

This study presents the structure of primate ferroportin and elucidates its mechanism of iron transport and regulation by hepcidin.

The paper isolates and characterizes SARS-CoV-2 from the first US COVID-19 patient, showing high replication in Vero cells and depositing the strain for public use.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

The paper identifies a conserved Ebola Zaire epitope that provides protection in mice and suggests its potential application in COVID-19 vaccine design.

This study identifies a novel RecJ from Bacillus alcalophilus with endonuclease activity, distinct from previously known exonucleases, and highlights its potential as a gene editing tool.

This study investigates the effect of Dedu Safflower Powder on ascites hepatocarcinoma using H22 mouse models and identifies the miR-23a-DAPK1-PVT1 signal axis as a potential mechanism.

This study shows infrared heater warming reduces dew formation by 41.6%-91.1% and shortens its duration by 32.1 days in alpine grasslands.

This study shows that mitochondrial respiration via PDH controls the speed of muscle stem cell activation, which declines with age, and that restoring PDH activity can improve muscle regeneration in aged mice.

The paper quantifies vertebrate biodiversity in Ailaoshan reserve using leech iDNA, showing species richness increases with elevation and distance from the reserve edge.

This paper introduces a method to measure aptamer folding energy using a molecular clamp and validates it with experimental results for two aptamers.

This study shows that weak predation strength promotes stable coexistence of predators and prey in food webs, supported by empirical data from plankton communities.

This study examines the relationship between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes, finding associations between axial length, lens power, and AL/CR ratio with DR risk.

This study shows that silicon enhances plant resistance against powdery mildew through distinct, multi-layered defense mechanisms involving PAD4-dependent and SA-independent pathways.