L. Xie

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

This study shows that deuteration of small-molecule fluorophores enhances their brightness, chromostability, and photostability in cellular imaging.

The paper uses simulations to study how artificial selection can improve microbial community function by modifying ecological interactions to enhance heritability and selection efficacy.

This study shows that SWELL1 regulates endothelial AKT-eNOS and mTOR signaling, affecting vascular function and contributing to hypertension and vascular narrowing in Type 2 diabetes.

This study identifies the SWELL1-LRRC8 complex as a mechanosensor regulating skeletal muscle size, signaling, adiposity, and glucose metabolism through PI3K-AKT-mTOR pathways.

This study shows BMPER deficiency leads to insulin resistance and hyperglycemia, and BMPER therapy improves these conditions in mice.

This study shows that Bcl6 deletion in Treg cells reduces tumor growth by impairing their suppressive function, and increased Bcl6 expression is linked to poor cancer outcomes.

This study compares SARS-CoV-2 and SARS-CoV spike-RBD binding to ACE2, showing similar affinities but differing neutralizing antibody cross-reactivity, highlighting challenges for broad-spectrum vaccines.

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

This study identifies MARCH5 as a mediator of NOXA-dependent MCL1 degradation in prostate cancer, enhancing apoptosis when combined with BH3 mimetics.

This paper develops a method to produce human amniotic epithelial cells-only membrane with higher purity and clinical potential for wound healing.

The paper develops a robust CNN for diabetic retinopathy screening by addressing dataset size, data curation, and performance metrics using cloud-based methods.

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.

The paper uses a genome-wide CRISPR screen to identify ZCCHC14 as a host factor required for hepatitis B surface antigen production and shows it stabilizes HBsAg through RNA tailing with TENT4A/B.

This paper establishes the first reverse genetics system for a segmented negative-strand RNA plant virus, enabling molecular genetic analysis of its life cycle and pathogenicity.

The paper identifies 202 differentially expressed genes in EBV-induced lymphomas using a mouse model and highlights key genes involved in the oncogenic process.

This study identifies key gut bacteria correlated with systemic iron levels using a murine model and bioinformatic tools, establishing a non-invasive prediction model for iron-related diseases.

This paper develops a spatiotemporal ventricular myocyte model that integrates mitochondrial Ca2+ cycling and ROS signaling to study their effects on intracellular Ca2+ dynamics and action potential behavior.

The paper simulates artificial community selection in two-species microbial communities and finds that stochastic fluctuations hinder function improvement, but cell sorting can enable successful selection.

This study shows that pre-infection modulation of host glycolysis with 2-DG enhances resistance to M. marinum infection by reducing phagocytosis and bacterial proliferation.

The paper identifies and resolves challenges in modeling microbial community dynamics by re-measuring strain phenotypes in community-like environments.

This study uses time-lapse microscopy to quantify birth and death rates of yeast mutants in different metabolite concentrations, revealing non-intuitive dynamics better modeled by the Moser model.

This paper introduces a compressed sensing-based method to predict serious rare adverse reactions of novel chemicals, showing improved accuracy with more known ADRs for a drug.

This study shows that condensin is essential for anaphase chromosome segregation and normal chromosome architecture formation, but not for chromatin compaction during mitosis.

This study identifies SWELL1 as a glucose sensor in β-cells that links glucose-induced swelling to chloride current activation, which is required for glucose-stimulated insulin secretion.

This study examines gut microbiota changes in rats with methamphetamine-induced conditioned place preference, finding reduced propionate-producing bacteria and altered microbial diversity.

This paper studies the binding mechanism of MEK type-III inhibitors to inform the design of new allosteric kinase inhibitors across the human kinome.