L. Yang

This study shows obesity disrupts pituitary UPR, leading to NAFLD, and demonstrates that restoring pituitary UPR can ameliorate metabolic defects.

This study analyzes genomic diversity in Asian white birch to identify signals of adaptation and hybridization, finding 7,609 SNPs associated with environmental variables and highlighting climate change risks.

This study investigates how L-norepinephrine affects wastewater microbiomes, showing it induces community shifts, oxidative stress, metabolic changes, and increased virulence potential.

The paper was withdrawn due to insufficient cell culture data to clarify the mechanism of ticagrelor and aspirin's effect on the gut microbiome and immuno-inflammatory response in atherosclerosis.

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

This study identifies FAK as a driver of therapy resistance in HPV-negative HNSCC, showing its role is dependent on mutant TP53.

This study evaluates an intranasal parainfluenza virus-vectored SARS-CoV-2 vaccine in macaques, showing it induces mucosal and systemic immunity and protects against viral challenge.

This study identifies self-organized canals in bacterial colonies that enable long-range directed transport of cells and vesicles, driven by biosurfactant-mediated fluid flows.

This study identifies VPS9D1-AS1 as a lncRNA that enhances TGF-β signaling and immune evasion in colorectal cancer by modulating translation and ISG expression.

This paper proposes strategies to extract fibril structure and tissue organization information from SAXS data of fibrils in tissue thin sections, leveraging micro- and nano-beam x-ray scattering.

The paper investigates freeze tolerance in the Amur sleeper using genomic, transcriptomic, and metabolomic analyses to identify genetic and molecular mechanisms underlying this adaptation.

The paper shows that Arabidopsis HSC70.1 binds its own mRNA to inhibit translation, forming a feedback loop that regulates chaperone availability and enables non-cell-autonomous homeostasis.

This study uses a transgenic mouse model to show that sustained HOTAIR expression promotes breast cancer metastasis and that its removal reverses metastatic traits, indicating an erasable epigenetic memory.

The paper compiles a global dataset of SARS-CoV-2 events in animals using health databases and provides tools for data validation and exploration.

This study compares antibody neutralization efficacy against SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, BA.2, and BA.3, showing increased resistance and the benefit of vaccine boosters.

This study introduces a new remote sensing index for urban ecological monitoring by integrating air quality data with existing ecological factors, showing improved assessment in Beijing.

This study shows that music increases protein content and photosynthetic efficiency in duckweed and activates Glu and Ca signaling, with transcriptomic changes linked to metabolic pathways.

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

This study identifies genomic rearrangements and regulatory changes in the little skate that contribute to the evolution of wing-like fin appendages.

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

The paper identifies a small molecule inhibitor of PDE6D-RAS interaction that shows anti-leukemic effects by blocking RAC activation in RAS-mutated cells.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This study evaluates an Omicron-specific mRNA vaccine, showing it elicits strong antibody responses and outperforms WT boosters against Omicron and Delta variants.

LIFE-Seq is a method for analyzing transgene integration in GMOs using DNA probes and PacBio sequencing, offering improved accuracy and cost-effectiveness compared to whole-genome sequencing.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.

The paper introduces a rapid, highly multiplexed protein detection method for brain tissue, enabling simultaneous detection of 31 proteins in 2 hours with high sensitivity and resolution.

This paper introduces a high-multiplex single-cell proteomics technology called Cyclic MIST to measure 465 proteins, enabling comprehensive immune cell subpopulation classification.

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

The paper investigates how intramolecular epistasis affects the evolution of CTS-resistant Na,K-ATPases, finding that resistance substitutions have pleiotropic effects independent of sequence divergence.