L. Yang

Doxorubicin inhibits phosphatidylserine decarboxylase and confers broad-spectrum antifungal activity

The paper shows doxorubicin inhibits MoPSD2, a phosphatidylserine decarboxylase in Magnaporthe oryzae, reducing fungal growth and crop disease severity.

Ser14-RPN6 Phosphorylation Mediates the Activation of 26S Proteasomes by cAMP and Protects against Cardiac Proteotoxic Stress in Mice

A parasitoid serpin gene that disrupts host immunity shows adaptive evolution of alternative splicing

The paper studies the evolution of alternative splicing and gene duplication in a parasitoid serpin gene, finding they jointly contribute to protein diversity and show divergent evolutionary patterns.

Hepatic IRE1 Protects Against Septic Cardiac Failure

This study shows that hepatic IRE1 protects against septic cardiac failure by maintaining lipid metabolic balance, independent of inflammation.

Perturbomics of tumor-infiltrating NK cells

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

Therapeutic immune cell engineering with an mRNA : AAV-Sleeping Beauty composite system

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

Predatory fireflies and their toxic firefly prey have evolved distinct toxin resistancestrategies.

This study shows that predatory fireflies and their toxic prey have evolved distinct toxin resistance strategies through gene duplication and neofunctionalization.

Drug-tolerant persister B-cell precursor acute lymphoblastic leukemia cells

The paper identifies genes and pathways contributing to drug-tolerant persistence of B-cell precursor acute lymphoblastic leukemia cells under chemotherapy.

High resolution cryo-EM and crystallographic snapshots of the large actinobacterial 2-oxoglutarate dehydrogenase: an all-in-one fusion with unique properties

This paper presents high-resolution cryo-EM and crystallographic structures of the actinobacterial 2-oxoglutarate dehydrogenase OdhA, revealing its unique all-in-one architecture and regulatory mechanisms.

Shoot maturation strengthens FLS2-mediated resistance to Pseudomonas syringae

The paper shows that FLS2-mediated resistance to Pseudomonas syringae strengthens with shoot maturation through microRNA156 regulation of callose deposition.

An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

Avirulent ME49Δgra5 Protecting Hosts Against Toxoplasma gondii Infection and Breast Tumors

This paper shows that the gra5 knockout T. gondii strain ME49Δgra5 is avirulent, prevents cyst formation, and protects against T. gondii infection and breast tumor growth in mice.

ABI5-FLZ13 Module Transcriptionally Represses Growth-related Genes to Delay Seed Germination in Response to ABA

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

Label-Free Mammalian Cell Tracking Enhanced by Precomputed Velocity Fields

This paper introduces a cell tracking method for label-free phase contrast imaging in microfluidic devices, improving tracking accuracy by incorporating velocity fields and modifying DeepSORT.

Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

The paper uses ex vivo perturbations on human lung slices combined with single-cell RNA-seq to study fibrogenesis, showing similarities to in vivo cell circuits and drug effects.

Trophoblast organoids with physiological polarity model placental structure and function

The paper develops trophoblast organoids with physiological polarity to model placental structure and function, showing improved hormone secretion and syncytium size.

HYENA detects oncogenes activated by distal enhancers in cancer

HYENA identifies oncogenes, including non-coding genes, activated by enhancer hijacking in cancer using whole-genome and transcriptome sequencing data.

A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors

The paper identifies a shared ubiquitin-proteasome pathway for degrading TOC and TOM tail-anchored receptors in Arabidopsis thaliana.

High-quality nuclear genome and mitogenome of Bipolaris sorokiniana strain LK93, a devastating pathogen causing wheat root rot

The paper sequences and assembles the nuclear and mitochondrial genomes of Bipolaris sorokiniana strain LK93 to improve understanding of its interaction with wheat.

Distinct function of SPL genes in age-related resistance in Arabidopsis

This study identifies SPL genes, particularly SPL10, as activators of age-related resistance in Arabidopsis during vegetative phase change by enhancing the salicylic acid pathway.

Disorganization of basement membrane zone architecture causes impaired melanocyte inhabitation in vitiligo

This study identifies disorganized basement membrane zone architecture and MMP2 overexpression in dermal fibroblasts as contributors to melanocyte loss in vitiligo.

Mechanisms that promote the evolution of cross-reactive antibodies upon vaccination with designed influenza immunogens

The paper develops a computational model to study antibody evolution after vaccination with designed influenza immunogens, finding that a chimeric antigen outperforms a cocktail in eliciting RBS-directed antibodies due to T cell interactions.

The direct interaction with transcriptional factor TEAD4 implied a straightforward regulation mechanism of tumor suppressor NF2

This study identifies a direct interaction between NF2 and TEAD4, showing NF2 inhibits TEAD4 stability and function, revealing a new mechanism of NF2's tumor suppressor role via the Hippo pathway.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Highly synchronized cortical circuit dynamics mediate spontaneous pain

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain

The paper shows that antigen presentation dynamics after multiple vaccinations influence the immune response to SARS-CoV-2 Omicron by shaping B cell responses and antibody targeting of epitopes.

An evolutionarily conserved pacemaker role for HCN ion channels in smooth muscle

This study identifies HCN ion channels as evolutionarily conserved pacemakers in smooth muscle, showing their role in peristalsis and pacemaker activity in the urinary tract.

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

Neutralization of Omicron BA.4/BA.5 and BA.2.75 by Booster Vaccination or BA.2 Breakthrough Infection Sera

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.