L. Yang

This paper describes a new early-branching armoured dinosaur from the Lower Jurassic of China, providing insights into the early diversification of thyreophorans.

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

The paper develops genetically encoded fluorescent potassium indicators with tunable binding affinities through structure-guided design and genome mining, showing varying Kd values in vitro and in cells.

This study quantifies TCA flux in tumors and healthy tissues, finding suppressed ATP production in tumors despite increased glycolysis.

This study assesses the future suitability of breadfruit cultivation under climate change scenarios, finding potential for expansion in sub-Saharan Africa but reduced yield quality under high emission scenarios.

The paper shows mechanical loading and hyperosmolarity reset circadian clocks in skeletal tissues via the mTORC2-AKT-GSK3β pathway, inducing rhythmic gene expression.

The paper investigates SARS-CoV2-induced inflammatory responses in monocytes using in vitro co-cultures, identifying a virus-specific gene cluster distinct from other viruses.

This study evaluates eVLP-based vaccine candidates against SARS-CoV-2 variants, showing that a trivalent vaccine induces broader immunity compared to single-variant vaccines.

This study shows that inhibiting stromal Galectin-3 enhances chemotherapy effectiveness in BCP-ALL by disrupting leukemia cell migration, adhesion, and drug resistance.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study shows Galectin-1 and Galectin-3 promote BCP-ALL cell growth and survival through intrinsic and extrinsic mechanisms, and their inhibition increases chemotherapy sensitivity.

This study identifies genetic transcript regulation and cyclohexane release as factors enhancing duckweed regeneration through callus formation.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This paper presents a data-driven workflow to design microbial strains using aggregated ALE mutational data, revealing gene-centric mutations that significantly alter cellular states.

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

This study shows that exosomal miR-328 from lung adenocarcinoma cells promotes osteoclastogenesis by targeting Nrp2 and suggests its inhibitors as a potential treatment for bone metastasis.

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

This paper introgresses type-IV glandular trichomes from S. galapagense into tomato, revealing genetic complexity in trichome development and acylsugar production.

OsciDrop generates size-tunable, monodisperse droplets on demand without microfabrication, enabling chip-free droplet assays for applications like virus quantification.

The paper introduces a single-cell cyclic multiplex in situ tagging (CycMIST) technology to comprehensively profile functional proteins in single neurons, demonstrating its ability to detect 182 proteins in a neuron cell line and reveal differential expression in an Alzheimer's disease model.

The paper identifies 66 compounds that inhibit SARS-CoV-2 replication and 24 that synergize with remdesivir, suggesting potential oral drug repositioning candidates for COVID-19.

The paper shows that liver generates NADPH for lipogenesis through serine catabolism, distinct from adipose which uses glucose and the pentose phosphate pathway.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

This paper introduces fBSA-Au, a bimodal endocytic tracer for 2D and 3D CLEM, enabling accurate registration of fluorescence to EM data with sub-200 nm precision.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study examines soil bacterial and fungal community patterns and co-occurrence networks along depth and altitude gradients in cold-temperate forests, finding altitude has a stronger impact than depth.

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

This study shows that HDAC5 deacetylates IFIT2, promoting glioma stemness and progression by inducing IFIT2 ubiquitination and loss of anti-tumor activity.

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.