M. Wu

This study identifies a direct interaction between NF2 and TEAD4, showing NF2 inhibits TEAD4 stability and function, revealing a new mechanism of NF2's tumor suppressor role via the Hippo pathway.

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

The paper identifies rear cortex contraction as a mechanism that increases intracellular pressure to facilitate nuclear transit during confined cell migration.

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

This study shows JAZ8 interacts with geminiviral C2 proteins and limits viral infection in Arabidopsis.

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

This study shows that regulating TAK1 activity can improve dystrophic muscle symptoms in a Duchenne muscular dystrophy mouse model.

The paper compares exercise and antioxidant intervention in type 2 diabetic rats, showing both improve blood glucose via hepatic AMPK activation and redox balance, with exercise promoting moderate ROS for AMPK activation.

This paper introduces PathFinder, an interpretable AI framework for discovering new tissue biomarkers in liver cancer, identifying tumor necrosis as a prognostic factor.

The paper develops a mathematical framework to infer exocytosis profiles from cell morphology in self-similar tip-growing cells and applies it to experimental data across species.

This study investigates calcium-independent ER-PM contact site oscillations in RBL mast cells and their role in SOCE, showing PI(4)P dependency and the importance of reversible contact sites for calcium oscillations.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

This study shows that SARS-CoV-2 S2-targeted vaccination induces broad neutralizing antibodies against multiple coronaviruses and provides better protection than homologous boosting.

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This paper develops a continuum model to study how elastic stresses and active relaxation in tumors regulate growth and size under mechanical confinement and chemical gradients.

The paper develops RasperGade16S to model 16S rRNA gene copy number uncertainty, showing it improves GCN prediction and supports correction in most microbial communities.

This study identifies distinct immune and malignant cell phenotypes in ovarian cancer linked to specific mutational processes and anatomic sites.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

This study uses scRNA-seq to analyze lung cellular heterogeneity and host response during severe influenza infection in mice, identifying key immune and non-immune cell changes and communication dynamics.

This paper presents a data-driven workflow to design microbial strains using aggregated ALE mutational data, revealing gene-centric mutations that significantly alter cellular states.

This study identifies BcPTP1 as a phytotoxic effector secreted by Botrytis cinerea during late infection, which induces cell death and promotes lesion spreading.

This study identifies four small molecule inhibitors of SARS-CoV-2 nsp14 RNA cap methyltransferase, with three showing synergy with remdesivir in antiviral assays.

This study shows that Tmem138 is essential for rhodopsin transport across the photoreceptor connecting cilium and outer segment biogenesis, with its absence causing photoreceptor degeneration.

This study identifies AK-778-XXMU as a potent ID2 antagonist with potential as a glioma therapeutic through pharmacophore-based virtual screening and experimental validation.

The paper analyzes microbial genomic trait evolution and finds that pulsed evolution is prevalent and predominant, with two distinct types of pulses detected.

This study screens a chemical library to identify SARS-CoV-2 RdRp inhibitors, finding three novel compounds and confirming suramin-like compounds as inhibitors.