M. Wu

This study identifies small molecule inhibitors of SARS-CoV-2 nsp5 main protease, finding calpain inhibitor I and peptidyl fluoromethylketones with potent antiviral activity.

This study identifies patulin and aurintricarboxylic acid as inhibitors of SARS-CoV-2 nsp14 exoribonuclease, showing antiviral activity in cell culture.

This study identifies two small molecule inhibitors of SARS-CoV-2 Nsp3 PLpro that inhibit viral replication in cell culture.

This study screens for small molecule inhibitors of SARS-CoV-2 nsp15 endoribonuclease and identifies NSC95397 as an in vitro inhibitor, though its antiviral efficacy remains to be determined.

This study identifies small molecule inhibitors of SARS-CoV-2 nsp13 helicase by screening a chemical library and validates their antiviral efficacy in cell culture.

This study shows that viral proteins interact combinatorially, leading to new biological functions beyond their individual roles during infection.

The paper compares SARS-CoV-2 replication in pediatric and adult nasal epithelial cells, finding lower viral titers in children for ancestral and Delta variants, but higher replication for Omicron.

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

The paper classifies neoantigens based on immune interactions and improves their prioritization for cancer immunotherapy.

This study uses visible-light OCT to analyze IPL sublayers in glaucoma and healthy subjects, finding that middle sublayer thinning is most significant in glaucoma.

This study shows that non-enzymatic acetylation of lysine residues in Rubisco activase reduces its stability and ATPase activity under varying light and heat stress conditions.

The paper uses a microfluidic organ-on-a-chip model to identify commensal bacteria that enhance host tolerance to infection, finding Enterococcus faecium promotes tolerance.

This study finds that reproductive proteins in Solanum species evolve faster than non-reproductive proteins, with female-specific loci showing stronger evolutionary rates than male-specific ones.

This paper introduces an automated framework for detecting and tracking ants in videos, achieving high accuracy and speed in both indoor and outdoor environments.

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

This study identifies the CoREST repressor complex as a mediator of melanoma phenotype switching and therapy resistance, showing that its inhibitor corin can reverse resistance to BRAF inhibitors.

This study shows that silencing LdCPR in Colorado potato beetles increases imidacloprid susceptibility, reduces fecundity, and causes embryonic lethality.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.

The paper identifies a novel copper-sensing two-component system, DsbRS, in Pseudomonas aeruginosa that activates the dsbDEG operon involved in copper resistance.

This study shows that the intrinsically disordered region of FBP17, not its F-BAR domain, is responsible for curvature sensing in membrane dynamics.

The paper analyzes ANI values across microbial genomes and argues that the observed bimodal distribution does not support a universal genetic boundary due to sampling biases and inflated benchmarks.

The paper generates the first genome sequence of a dioecious Solanum species and identifies the genetic basis of sex determination, finding males are the heterogametic sex and sex-specific genes are involved in pectin degradation.

This study identifies DNA polymerases alpha and delta as key mediators of geminivirus replication in plants, with C3 protein selectively recruiting polymerase delta for efficient viral genome synthesis.

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

The paper studies how rat embryonic fibroblast monolayers form radial symmetry under confinement, showing that contractility and cell-cell adhesion drive this structure.

The paper examines how autophagy and mitochondrial fission impact the Harderian gland in male hamsters under different photoperiods, finding autophagy levels correlate with gland weight changes.

This study evaluates the cytotoxicity of chloroquine and hydroxychloroquine in multiple cell lines and tissues using a dynamic imaging system and PBPK model, finding HCQ less toxic than CQ in most cases.

This study shows remdesivir reduces renal fibrosis in obstructed kidneys without affecting renal or liver function.

The paper compares embolism resistance between root and stem xylem in three woody angiosperms, finding roots are more resistant in some species but not all.