M. Wu

This paper introduces FucoID, a method to detect and isolate tumor-specific antigen-reactive T cells from tumor-infiltrating lymphocytes using fucosyl-biotinylation, revealing distinct gene features and functional capabilities.

This study uses MRI modalities and machine learning to predict amyloid-β burden in the brain, showing that combined T1, T2, and SWI images perform best.

This study links cellular virological stages in chronic hepatitis B to liver fibrosis progression through spatial and functional analysis of viral and host gene expression.

This study uses scRNA-seq to analyze renal and skin biopsies from lupus nephritis patients, identifying IFN signatures and fibrotic pathways associated with disease heterogeneity and non-response.

The paper uses live cell imaging to show clathrin-coated pits develop curvature early without requiring a flat-to-curved transition.

This study shows that a 200 keV cryo-EM microscope can achieve 1.7 Å resolution for macromolecular structures, comparable to higher voltage systems.

This study identifies a pathway connecting plasma membrane and chloroplasts that pathogens exploit to suppress salicylic acid-dependent defenses.

This study shows that adding extracellular polymer substances (EPS) increases methane production in anaerobic digestion by enhancing microbial communities and electron transfer, without affecting sludge properties.

This study identifies GUARDIN as a key regulator of cellular senescence through a LRP130-PGC1α-FOXO4-p21 signaling axis and shows its role in enhancing rapamycin's anti-senolytic effects.

The paper develops a method to image sub-organellar actin dynamics using fluorescent actin nanobodies and finds ER-associated actin drives organelle fission.

This study evolves E. coli under acid stress and identifies genetic and expression changes that enhance acid tolerance.

This paper shows myosin-Va facilitates mitochondrial fission in melanoma cells by interacting with Spire1C and localizing to fission sites, linking it to the Warburg effect.

This study examines the evolution of cardenolide insensitivity in Orthoptera, finding predictable patterns similar to other insect orders and identifying sites under positive selection.

This study reports cryo-EM structures of TRPM2 channel in intermediate states to elucidate structural transitions during ligand-dependent gating.

This paper introduces a flexible docking method for protein-ligand interactions using mixed-resolution Monte Carlo, showing improved performance over existing methods for estrogen receptor α.

The paper demonstrates that conventional cryo-EM can determine high-resolution structures of sub-100 kDa complexes, resolving ligands and conformational states with sub-nanometer precision.

This study shows IL-8 promotes cellular plasticity and therapeutic resistance in glioblastoma by altering epigenetic marks and enhancing cancer initiating cell properties.

The paper presents cryo-EM structures of human TRPV3 in different states to elucidate its sensitization and gating mechanisms.

The paper reports the high-quality genome of Jaltomata sinuosa, identifies gene family dynamics, and provides insights into reproductive trait evolution in the Solanaceae family.

This study identifies extracellular HBV RNAs as heterogeneous in length, present in virions and capsid-antibody-complexes in CHB patients, and capable of serving as templates for viral DNA synthesis.

This study shows SlARF10 regulates chlorophyll and sugar accumulation in tomato fruits by controlling starch synthesis and photosynthesis.

The paper analyzes genetic data from Yangtze finless porpoises to show population fragmentation, low genetic diversity, and recent decline linked to habitat degradation and human activity.

The paper investigates trait evolution in Jaltomata, finding gene tree discordance affects floral trait inferences but not fruit color, and identifies candidate loci for adaptive evolution.

This study presents a method for 3D morphological reconstruction and force inference in early C. elegans embryos, showing deviations of 7% and 10% from force balance and Young-Laplace relations.

The paper shows membrane curvature drives collective dynamics of cortical proteins through mechanochemical feedback, influencing wave propagation and spatiotemporal patterns.

This paper shows that 200 keV TEMs can achieve cryo-EM resolutions better than 3 Å, enabling detailed structural analysis previously thought possible only with 300 keV TEMs.

This paper develops a fast and stable signal deconvolution method using compressible state-space models, showing improved performance on calcium imaging and sleep spindle detection.