P. Huang

This study identifies co-regulated splicing factor expression as a defining feature of intravenous leiomyomatosis through proteomic analysis.

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

The paper identifies and deletes 19 Myb genes in Magnaporthe oryzae, finds most are expressed during infection, and identifies co-regulated groups with potential roles in pathogenicity.

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

This study identifies plakoglobin and HMGB1 as key mediators of TcdB-induced intestinal epithelial cell apoptosis through mitochondrial pathways.

This study identifies MARCH1 and MARCH8 as specialized regulators of CD4+ T cell immunity in distinct cellular compartments by analyzing their substrates and expression in mice.

This study shows olanzapine induces NAFLD via the apoA5 pathway by increasing hepatic apoA5 protein and sortilin levels, with APOA5 knockdown reversing steatosis.

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

This study investigates the neuroprotective role of CTRP1 in TBI rats, finding it reduces inflammation and modulates autophagy through mTOR activation.

The paper introduces six mutants of β-glucosidase B and adds their catalytic activity and thermal stability data to the Design2Data database.

This paper introduces a simplified agarose microbead-based SiMPull method that is faster, easier, and more reproducible than the original technique while maintaining similar sensitivity and signal-to-noise ratio.

This study computationally designs two new soluble epoxide hydrolase (sEH) inhibitors with improved pharmacokinetic properties and docking scores compared to t-TUCB.

This paper develops a biophysical model to predict RNA stability and demonstrates that superfolder mRNAs can increase in vitro half-life by at least two-fold through AUP optimization.

This study designs two novel SSRIs with better docking scores than paroxetine using computational methods and identifies mice as a suitable preclinical model.

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

This study shows that microbubble-mediated cavitation induces apoptosis and reduces invasion in AsPC-1 cancer cells through increased calcium, cleaved Caspase-3, BAX, and decreased Bcl-2, HIF-1, and Vimentin.

This paper identifies a novel protein complex in Arabidopsis that regulates ROS1-mediated active DNA demethylation and targets ROS1 to specific genomic regions.

The paper quantifies thermal stability and catalytic efficiency of six β-glucosidase B mutants and adds the data to a dataset to improve Rosetta algorithms for protein engineering.

The paper evaluates five computational tools for predicting thermal stability and soluble protein production in enzyme mutants using an expanded dataset of 51 β-glucosidase mutants.

The paper introduces three new mutants of β-glucosidase B to expand a dataset for training computational enzyme design algorithms and exploring structure-function relationships.

The paper identifies fibroblast-expressed PIK3Cδ as a key driver of triple-negative breast cancer progression through paracrine signaling and shows its prognostic significance.

This study identifies and characterizes DCT4, a new dicarboxylate transporter in C4 grasses, showing its role in malate transport during photosynthesis and sub-functionalization in the PACMAD clade.

This paper describes the synthesis of cyclopentadecanone and cyclopentadecanolide from Malania oleifera Chum oil through ozonolysis, esterification, and cyclization reactions with reported yields.

This study identifies iRhom2 as a key regulator that promotes obesity-associated metabolic disorder by enhancing adipose inflammation and insulin resistance.

The paper identifies immune-suppression signatures in glioblastoma (GBM) patients, showing elevated myeloid-derived suppressor cells (MDSCs) linked to poor prognosis and reduced survival.

The paper evaluates the PURE system for in vitro protein synthesis, identifying factors affecting protein yield and activity, and proposes optimizations to improve performance.