Q. Zhang

This study combines transcriptome and metabolome analysis to identify molecular responses of Desmodesmus sp. to sewage treatment, revealing key pathways and metabolite changes.

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

This study identifies a pan-cancer class of tumors driven by replicative instability, showing it accelerates cancer progression through genomic changes and transcriptional rewiring.

The paper investigates how mechanical communication between cells leads to directional migration and branching connections, mediated by calcium channels, integrin β1, and N-cadherin.

This study reveals the substrate translocation mechanism in P-glycoprotein by determining cryoEM structures and using molecular dynamics simulations to identify conformational changes in TM1 that regulate transport.

This study evaluates a multivalent mRNA vaccine encoding SARS-CoV-2 and SARS-CoV receptor-binding domains, showing it induces cross-neutralizing antibodies against multiple variants in mice.

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

This paper uses network mapping to identify plant genes and SNPs that influence microbial network architecture in Arabidopsis thaliana, revealing genetic control of microbial interactions and their impact on plant traits.

The paper presents a power electronic system and magnetic nanoparticles enabling three-channel magnetogenetic neurostimulation with selective heating across different frequency ranges.

This study identifies oxidative phosphorylation pathway disruption as an alternative mechanism causing Diamond-Blackfan anemia and shows coenzyme Q10 can rescue erythroid defects.

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

This study shows that asymmetric ABA response in tomato root tips mediates proton efflux and cell elongation, driving hydrotropic bending toward water.

The paper proposes a dynamic kissing model for enhancer-promoter communication within transcriptional condensates, supported by experimental data showing preference for spherical surface confinement.

This study shows that PLC-gamma1 becomes active upon binding to FGFR1 kinase domain and membrane-bound PIP2, with an oncogenic mutation enhancing this activation.

The paper reports the NMR solution structure of the SetA-CTD domain from Legionella pneumophila, revealing its PI(3)P binding mechanism and structural features important for membrane association.

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

This study shows that Cdk11 promotes centromeric transcription to maintain cohesion during mitosis by phosphorylating RNAPII.

The paper shows that phosphatidic acid, produced by phospholipase Dδ, mediates the nuclear translocation of cytosolic GAPC under heat stress in plants.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

This study identifies MIG-23 as a key regulator of sperm migration in Ascaris suum by modulating extracellular ATP levels through ecto-ATPase activity.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

This study shows that loss of PTEN and hemidesmosomes in prostate cancer promotes tumorigenesis by activating EGFR/PI3K/Akt and FAK/Src pathways through plectin mislocalization.

The paper examines how dominant species influence ecosystem stability across different spatial scales in Inner Mongolian grassland, finding that stability is linked to dominant species dynamics and precipitation patterns.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.