Q. Zhang

This study identifies TEAD1 as a regulator of ITGA1 and ITGA2 in prostate cancer, showing their loss promotes tumor progression via TGFβ1-driven EMT.

This paper discovers and engineers an L-threonine aldolase from Neptunomonas marine to efficiently synthesize β-hydroxy-α-amino acids with high diastereoselectivity.

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

This study shows HCC-1 promotes atherosclerosis by inducing pyroptosis in endothelial cells and macrophages and suggests it as an early diagnostic biomarker.

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

This study identifies HIF2/ARNT as a protective axis in cardiac endothelial cells post-MI, preventing vascular leakage and inflammation through suppression of IL6.

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

This study shows that medium volume in RPE cell cultures affects O2 availability, altering metabolism and lipid droplet dynamics, and suggests optimal conditions for studying oxidative metabolism in RPE cells.

This study shows that ACE2 binding blocks RBD antigenicity, reducing neutralizing antibody production, and suggests improving vaccine efficacy by exposing RBD immunogenicity.

This study investigates the role of the NDH complex in maize by analyzing mutants, finding it regulates carbon flow and redox balance in C4 photosynthesis.

This paper introduces a 2D-HPLC method for analyzing the purity of bovine milk-derived exosomes, showing improved accuracy, precision, and efficiency compared to existing methods.

This study shows ulinastatin reduces cardiac ischemia/reperfusion injury by inhibiting the tissue kallikrein-kinin system and its downstream signaling pathways.

This study provides a comprehensive transcriptomic analysis of the cell wall stress response in Bacillus subtilis, identifying key regulatory factors and developing biosensors for envelope stress detection.

This study injects alpha-synuclein pre-formed fibrils into the prefrontal cortex of mice, showing spread to cortical and subcortical regions and mild behavioral changes.

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

This study shows caltubin enhances neurite regrowth in neurons by stabilizing microtubules through Ca2+-dependent mechanisms.

This study uses adaptive optical two-photon fluorescence microscopy to image ocular lens cellular organization in vivo, revealing novel structures and growth dynamics previously unseen in dissected lenses.

The paper introduces WIT, a context-aware transformer model for whole slide image classification, achieving higher accuracy than baseline methods across multiple cancer datasets.

This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.

This study identifies MYSM1 as an ER co-activator that promotes antiestrogen resistance in breast cancer through histone and non-histone deubiquitination.

An oral mRNA vaccine using bovine milk-derived exosomes encoding SARS-CoV-2 RBD induces neutralizing antibodies in mice.

This study shows gut bacteria influence uric acid levels and atherosclerosis in mice and humans by catabolizing purines.

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

This paper shows that human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection via ACE2 and demonstrates antiviral efficacy of remdesivir and GC376.

This study shows SARS-CoV-2 uses actin-rich filopodia for efficient viral entry, revealing two modes of entry and identifying potential antiviral targets.

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

This study identifies LINC01184 as a tumor-promotive factor in hepatocellular carcinoma, showing its overexpression correlates with poor patient outcomes and its role in promoting cell proliferation and migration.

This study identifies LINC02428 as a liver-specific lncRNA that suppresses hepatocellular carcinoma progression by inhibiting cell proliferation, migration, and inducing apoptosis.