R. Li

This study models adaptive therapy for non-muscle invasive bladder cancer to control tumor size and reduce recurrence by analyzing mutational heterogeneity and cytokine profiles.

This paper identifies a long non-coding RNA, EDAL, that inhibits neurotropic viruses by promoting EZH2 degradation through O-GlcNAcylation site interference.

This study shows that overexpression of PGRB promotes ovarian tumor development in mice, while PGRA reduces tumor frequency, highlighting the role of PGR isoforms in hormone-dependent neoplasia.

The paper quantifies how translation inhibition reduces transcription capacity by limiting free RNA polymerase availability, affecting gene expression based on mRNA length.

This study shows repeated hypoglycemia reduces GHRH neuron responsiveness by altering neural inputs and mitochondrial function, suggesting mitochondrial dynamics as a target for preventing hypoglycemia unawareness.

This study examines how melatonin affects wheat seed germination and amino acid content under PEG stress, finding that 300 μM melatonin improves germination metrics and lysine levels.

The paper introduces PIRCh-seq to profile chromatin-associated RNAs with histone modifications, identifying functional groups of lncRNAs and allele-specific interactions.

This study identifies FCRL6-expressing B cell progenitors that influence natural antibody selection through distinct pre-BCR dependent and independent pathways.

This study shows that hypertriglyceridemia and obesity worsen systemic inflammation and pancreatic injury in rats with severe acute pancreatitis.

The paper shows nuclear actin enhances RNA polymerase II clustering during inducible transcription, facilitating rapid gene expression in response to stimuli like serum and interferon-gamma.

The paper uses single-cell multi-omics to identify aberrant megakaryocyte pathways in myelofibrosis and discovers JAK2-mutant-specific targets for immunotherapy.

This study examines how varying forage-to-concentrate ratios in sheep diets affect rumen bacterial structure, nutrient levels, and methane production, identifying key bacterial genera correlated with these factors.

This study characterizes and repurposes the endogenous Type I-F CRISPR-Cas system of Zymomonas mobilis to create an efficient genome engineering toolkit with 100% efficiency in various genetic modifications.

This study characterizes PsBCAT, a branched-chain amino acid aminotransferase from Pseudomonas sp., showing broad substrate specificity and high activity, and demonstrates its application in efficient chiral amino acid synthesis.

The paper shows NPC2 interacts with LBPA to facilitate cholesterol trafficking from late endosomes/lysosomes, independent of NPC1.

The paper visualizes replication foci during S-phase and reveals a CTCF-dependent hierarchical radial propagation pattern that reverses directionality over time.

This study shows that HPV16 regulates SAMHD1 expression in oral keratinocytes, and SAMHD1 deletion enhances viral replication and cell proliferation in HPV16-infected cells.

This study identifies O-GlcNAc transferase as a suppressor of hepatocyte necroptosis and liver fibrosis, using both human and mouse models.

The paper shows that balancing selection maintains genetic diversity at immunity genes across Capsella species after population bottlenecks.

This study identifies herpesvirus protein kinases that phosphorylate SAMHD1 to inhibit its dNTPase activity, thereby evading host antiviral defenses.

This study identifies lysosomal function as a regulator of cellular quiescence depth, showing it acts like a dimmer switch to modulate quiescence and link it to senescence and aging.

The paper develops and validates a high-content imaging assay to assess antiviral activity of small-molecule inhibitors against Zika virus by detecting cytopathic effects.

This study develops a multi-hierarchical nano-SAR assessment for Fe2O3 nanomaterials, revealing how their properties influence bio-effects like cell migration and inflammation.