Philip Bejon

Targeting PTRAMP-CSS potently inhibits P. falciparum across blood, liver and mosquito stages

This study shows that targeting PTRAMP-CSS inhibits Plasmodium falciparum across liver, blood, and mosquito stages, supporting its potential as a multistage vaccine target.

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children

The paper identifies African-specific genetic loci associated with iron status and risk of severe malaria and bacteremia in children, highlighting limited transferability of European polygenic risk scores.

OxBreaker: species-agnostic pipeline for the analysis of outbreaks using nanopore sequencing

OxBreaker is a species-agnostic pipeline for analyzing bacterial and plasmid outbreaks using nanopore sequencing, offering high accuracy and accessibility for real-time genomic surveillance.

Uncovering the genetic diversity of the malaria parasite antigen MSP2 across Sub-Saharan Africa

The paper analyzes genetic diversity of the malaria parasite antigen MSP2 in Sub-Saharan Africa using PCR and long-read sequencing, revealing extensive sequence variation and regional prevalence patterns.

OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

A complex Plasmodium falciparum cryptotype circulating at low frequency across the African continent

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.

Validation of saline, PBS and a locally produced VTM at varying storage conditions to detect the SARS-CoV-2 virus by qRT-PCR

This study evaluates the performance of four viral transport media for preserving SARS-CoV-2 RNA during storage at different temperatures and time points.

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

The paper improves statistical power in severe malaria genetic studies by addressing phenotypic imprecision through a probabilistic diagnostic model and data-tilting approach.

Genome variation and population structure among 1,142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii

The paper analyzes genome variation in 1,142 Anopheles mosquitoes to study population structure and insecticide resistance.

Evaluating the performance of malaria genomics for inferring changes in transmission intensity using transmission modelling

This study evaluates genetic metrics for inferring malaria transmission intensity changes using a transmission model and finds one metric can predict prevalence with 0.055 mean absolute error.

Natural diversity of the malaria vector Anopheles gambiae

The paper sequences genomes of 765 malaria vector mosquitoes to study genetic diversity and insecticide resistance.