S. Chakraborty

This study investigates talin-drug interactions using single-molecule techniques, revealing biphasic mechanical effects and mechanistic insights into drug-induced stability changes.

This study identifies ALOX5 as a mediator of chemoresistance in AML by promoting LSC self-renewal through LTB4-BLTR signaling, suggesting ALOX5 inhibition could enhance chemotherapy efficacy.

This study identifies HP1β's chromo shadow domain as essential for promoting H2A ubiquitination and BRCA1 recruitment at DNA double-strand breaks to facilitate homologous recombination repair.

This study identifies nAbs against SIVmac239, reveals structural features of its Env trimer, and shows passive transfer of nAbs protects macaques from infection.

This study shows that antibiotic treatment of Salmonella Typhi can generate L-form bacteria that infect macrophages and mice, suggesting a mechanism for antibiotic resistance and disease transmission.

This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.

This study shows Leishmania manipulates host miRNA transport to suppress inflammation and promote its survival by exporting miR-146a and inhibiting miR-122 in neighboring cells.

The paper identifies regulators of legume-rhizobia symbiosis by analyzing temporal chromatin accessibility and gene expression in Medicago truncatula roots.

The paper identifies conserved noncoding sequences in nitrogen-fixing plants and shows their role in regulating genes involved in root nodule symbiosis.

This study identifies a novel mechanism where Wnt/β-catenin signaling and p68 regulate CHIP expression in colorectal cancer, promoting cell proliferation and migration.

This study shows DsbA acts as a redox-switchable mechanical chaperone, reducing ATP consumption for periplasmic translocation by up to 33%.

The paper uses spatial transcriptomics to identify molecular features of 5ALA+ infiltrative tumor cells in glioblastoma linked to recurrence and poor survival.

The paper identifies early antibody responses that predict COVID-19 severity and vaccine response, showing functional differences in inflammation regulation.

This study investigates how chaperones modulate talin mechanics under single-molecule resolution, showing they alter unfolding forces and energy landscapes.

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

The paper compares baseline cell proliferation rates and UV response in Lymphoblastoid Cell Lines from healthy individuals with different constitution types, finding significant differences in proliferation and recovery.

This study shows that CNGC2 modulates auxin homeostasis and signaling by influencing auxin biosynthesis and Ca2+ signaling in Arabidopsis.

This study shows the D614G mutation in SARS-CoV-2 Spike protein increases open conformations, enhancing infectivity and neutralization sensitivity.

This study shows that bacteria can modulate flagellar motor speed through ligand sensing, not just altering rotation bias, with metabolisable ligands causing prolonged speed increases.

This study uses molecular simulations to analyze how different glycan types on SARS-CoV-2 RBD and ACE2 affect their binding, finding that glycan presence does not alter the contact signature but influences binding affinity.

This study shows that in vivo protein nitration and denitration in Vibrio cholerae under anaerobic conditions enhance cell survival by managing nitrite and nitrate levels.

This study shows that ligand sensing in E. coli increases flagellar bundle tightness and swimming speed by enhancing motor torque and CCW bias, independent of metabolism.

This study examines how vancomycin, neomycin, and AVNM affect gut microbiota in C57BL/6 mice, showing differential changes in microbial composition, diversity, and host immune and metabolic responses.

The paper shows that inhibiting MMP2 on extracellular vesicles reduces miR-122 transfer to macrophages, thereby decreasing liver inflammation.

This study uses cryo-EM, computational modeling, and mass-spectrometry to analyze the HIV-1 Env glycan shield's structure and dynamics, revealing how heterogeneity and interactions affect epitope accessibility and trimer stability.

The paper uses magnetic-tweezers to study how chaperones respond to mechanical force, revealing their roles in generating or consuming energy during protein folding.

This paper develops and characterizes an mRNA-LNP vaccine candidate targeting the D614G variant of SARS-CoV-2, showing neutralizing antibody and balanced cellular immune responses in preclinical trials.

This study shows Rad4/XPC can open undamaged DNA in solution without specific β-hairpin motifs and reveals dynamic conformations of open DNA through crystal structures and fluorescence analysis.