S. Chen

This study extends the in vivo haploid induction system from diploid maize to hexaploid wheat by knocking out homologous genes, achieving 2%-3% haploid induction with 30%-60% seed setting rate.

This study identifies transcriptomic changes in guard cells of M. crystallinum during salt-induced C3 to CAM transition, showing guard cells can undergo this shift.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.

The paper identifies MISTERMINATE as a mechanism linking mitochondrial dysfunction to proteostasis failure through translational termination impairment and C-terminal extension of mitochondrial proteins.

This study uses multi-omics analysis to examine the effects of simulated weightlessness on rhesus macaques, identifying molecular changes in blood, muscle, brain regions, and fecal samples.

This study examines how different diets after weaning affect gut microbiota and susceptibility to DSS-induced colitis in mice, finding that high protein diets worsen colitis while high fiber diets reduce it.

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

This paper identifies metabolite pathways involved in oxidative stress responses of Aspergillus flavus over time, linking them to aflatoxin production and stress tolerance.

This study presents high-resolution cryo-EM structures of Hfq and Crc bound to an RNA, revealing their cooperative assembly and mechanism of gene regulation in Pseudomonas aeruginosa.

The paper introduces two methods for faster tilt-series acquisition in electron cryotomography, with trade-offs in resolution and speed.

This study reveals dynamic conformational landscapes of SETD8 using X-ray structures and molecular simulations, showing how protein dynamics influence catalysis and cancer-associated mutations.

This paper identifies nitrile oxide electrophiles as a new class of GPX4 inhibitors that overcome limitations of existing chloroacetamide-based inhibitors.

The paper identifies 6mer seed sequences in miRNAs that are toxic to cancer cells, showing that tumor suppressive miRNAs use these toxic seeds to kill cancer cells.

This study shows TP, activated by Twist1, promotes HCC metastasis and VM via pentose Warburg effect by linking pentose phosphate pathway and glycolysis.

This study examines how intra- and intermolecular triplet-state quenching affects photobleaching and photoswitching in fluorophores, showing competition between these processes and identifying new roles for intramolecular quenchers.

This study shows that deleting the ycgN gene in B. licheniformis increases gamma-PGA synthesis by raising intracellular ROS levels through P5C accumulation.

This study shows hemolysin facilitates cytosolic LPS sensing by liberating bacterial outer membrane vesicles, leading to inflammasome activation and gut inflammation.

The paper shows that siRNAs based on CAG TNRs are toxic to cancer cells and slow tumor growth in a mouse model without toxicity.

The paper determines the structure of the AMPA receptor-TARP complex using cryo-EM, revealing activation and desensitization mechanisms.

The paper uses synchrotron X-ray fluorescence imaging to analyze trace metal distribution in sulfate-reducing bacteria and methanogenic archaea at the single-cell level.

The paper presents uncharacterized bacterial structures observed via electron cryotomography to encourage their identification and study.

The paper determines the cryo-EM structure of the human proteasome regulatory particle bound to p28, revealing its dynamic conformational landscape and role in proteasome assembly.