S. Cheng

This study uses cryo-electron tomography to reveal the high-resolution 3D structure of human red blood cell membranes and their protein distribution.

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

The paper investigates how tau assemblies enter the cytosol, finding that cholesterol levels and specific cellular machinery are critical for this process, which is essential for seeded aggregation.

The paper develops a standardized proteomics workflow for high- and mid-throughput analysis of blood biofluids, showing reliable protein detection across different matrices.

The paper identifies and characterizes sequence motifs and ion selectivity mechanisms in channelrhodopsins from diverse algal and protist species using electrophysiological analysis and genomic data.

The paper shows that nuclear deformation during migration or compression causes DNA damage by increasing replication stress, primarily in S/G2 phase, independent of nuclear envelope rupture.

This study develops a cross-species drug discovery pipeline to identify and validate new treatments for osteosarcoma, finding that dual inhibition of proteasome and CRM1 pathways induces synergistic cytotoxicity.

The paper identifies a peroxidase inhibitor, 6D1, that enhances kanamycin activity against carbapenem-resistant bacteria.

This study demonstrates a method to recycle proteins into new functional proteins using a cell-free system, aligning with circular-economy principles.

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.

This paper shows HCMV drives WDR5 to the virion assembly compartment to facilitate virion assembly, expanding its role beyond nuclear egress.

This paper introduces a label-free imaging cytometry method using deep learning to predict subcellular features from reflectance microscopy, achieving higher accuracy and throughput for single-cell analysis.

The paper shows HOXB13 expression is reduced or lost in neuroendocrine prostate cancer (NEPCa) and that NEPCa tumors lose prostate-specific HOX codes without gaining a clear new tissue identity.

This study shows that loss of Aldob activates Akt, promoting hepatocellular carcinoma by destabilizing the Aldob/Akt/PP2A complex, and identifies SMAP as a potential therapeutic agent.

This paper develops an electronic blood vessel using flexible bio-degradable circuitry to enhance endothelization and enable gene delivery, showing good biocompatibility and patency in a rabbit model.

This study identifies aberrant MYB complex assembly as a driver of oncogenic gene expression in AML and shows that targeting this complex can induce differentiation and apoptosis.

This study examines how repeated extinction learning sessions affect behavior in pigeons, revealing session-specific variability and a decay in renewal effects over time.

This study shows that mTOR hyperactivation causes widespread exon skipping, leading to diverse proteomic changes through alternative splicing in both 5’-UTR and coding regions.

This study shows YAP1 is increased in high-grade prostate adenocarcinoma but reduced in neuroendocrine prostate cancer, with YAP1 loss activating Wnt/beta-Catenin signaling linked to NEPC development.

This study identifies lncRNA AVAN as a positive regulator of antiviral innate immunity by interacting with TRIM25 and enhancing FOXO3a transcription.

The paper shows that an ancestral signaling pathway is conserved in plant lineages with intracellular symbioses but lost in those with extracellular symbioses.

The paper assesses the frequency of deleterious mutations in 21 hereditary breast and ovarian cancer genes among 882 high-risk Chinese individuals, finding 19.5% carried such mutations, with higher rates in those with both breast and ovarian cancer histories.

This paper introduces a deep learning method for label-free optical oximetry that provides uncertainty quantification and demonstrates improved accuracy over traditional methods in rat retinal imaging.

This study shows low-dose IFN-γ promotes tumor stemness in NSCLC via ICAM1-PI3K-Akt-Notch1 pathway, while high-dose IFN-γ induces apoptosis through JAK1-STAT1-caspase pathway.

This paper develops a cross-species personalized medicine pipeline using canine sarcomas to identify new treatments, finding proteasome inhibitors initially effective but limited by tumor heterogeneity.

The paper identifies Dprs and DIPs as part of an ancient bilaterian receptor family involved in neural wiring, supported by phylogenetic, biochemical, and structural evidence.

The paper shows that chemotherapy induces cellular senescence in high-grade serous ovarian cancer, which correlates with better patient survival.

This paper develops a method to consistently measure Fj and Fi in PSII chlorophyll fluorescence induction by tracking curvature, improving accuracy under varying conditions.