S. Kim

The paper introduces a model showing DNA supercoiling drives a transition between cooperative and antagonistic RNA polymerase dynamics during gene synthesis.

This study elucidates the molecular mechanism of substrate recognition by the macrocyclase PsnB in graspetide biosynthesis, revealing key interactions and structural features.

This study shows ecosystem size and complexity equally influence riverine biodiversity across different regions.

This study analyzes the blood microbiome in a porcine model of fecal-induced peritonitis, finding stable bacterial populations and taxonomic differences between fecal and blood microbiomes.

The paper introduces ORACLE, a multiplexed reporter system for live imaging of cell fate dynamics in hPSCs, revealing insights into pluripotency exit and early differentiation.

This study develops a RBD-based nanoparticle vaccine against SARS-CoV-2 that protects ferrets from infection and reduces viral load.

The paper develops a model-based method to measure acoustic radiation force of ultrahigh frequency ultrasonic transducers using gelatin phantom experiments and validates it with FRET live cell imaging.

The paper identifies heme auxotrophy in the acI bacterial lineage and shows it is widespread in uncultivated microbial groups, suggesting heme could enhance microbial culture diversity.

The paper uses optical diffraction tomography to image and analyze 3D vasculogenesis in vitro without exogenous labeling.

This study shows that acute Myc suppression in adult mice prevents KRasG12D-driven lung and pancreatic cancers with minimal side effects when applied metronomically.

This paper introduces a phenotype-based drug response metric that improves pharmacogenomic analysis by providing time-independent and phenotype-relevant assessments of drug effects.

This study shows that platycodin D inhibits SARS-CoV-2 infection by blocking lysosome- and TMPRSS2-driven entry through membrane cholesterol redistribution.

This paper introduces thin-chip microfluidic devices with integrated valves, demonstrating their utility in high-resolution imaging and single-cell applications.

This study examines how cigarette smoke and COPD affect SARS-CoV-2 infection by analyzing ACE2 and TMPRSS2 expression in human and mouse lung tissues and an in vitro model.

This paper demonstrates high-resolution imaging of FDG uptake in a 3D tumor-stroma model using radioluminescence microscopy, showing significant FDG uptake in both tumor and stromal compartments.

This study shows that ClpA does not need to rotate relative to ClpP for proteolysis, though some flexibility may aid function.

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

This study shows that adding acyclovir to chemoradiation reduces viability of EBV-infected NPC cells by increasing TK and apoptosis markers.

This study characterizes ocular biometrics and retinal function in rhesus macaques, finding similarities to human eyes, particularly in macular structure and cone photoreceptor function.

The paper shows that the plant NLR CCA309 targets P-type ATPase to cause membrane depolarization, calcium influx, and cell death during hypersensitive response.

This paper introduces a cell-based assay to identify coronavirus 3CL protease inhibitors without live virus, demonstrating its effectiveness through compound screening and structure-activity profiling.

This paper proposes a new approach to developing selective therapeutics for infectious diseases by engineering bacteriocins inspired by natural bacterial mechanisms.

This study quantifies the biophysical differences in SARS-CoV-2 and SARS-CoV-1 RBD-ACE2 interactions using single-molecule force spectroscopy and SMD simulations, revealing a key N-glycan interaction in SARS-CoV-2 that enhances binding affinity.

This paper tests KDS2010, a reversible MAO-B inhibitor, in PD animal models and finds it effective with low toxicity and superior neuroprotection compared to selegiline.

This study compares qPCR and ddPCR for SARS-CoV-2 detection, finding ddPCR more sensitive and accurate in quantifying viral RNA from various sources.

The paper identifies stereotypic VH clonotypes against SARS-CoV-2 RBD in patients and healthy individuals, showing their pre-existing presence in the healthy population.

This study shows CDK2 activity coordinates cell-cycle commitment and DNA replication timing, with commitment occurring before DNA replication.

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

This study theoretically examines how fluid-to-solid tissue transitions control morphogenetic flows and shape during vertebrate body axis elongation, showing that tissue surface tension and fluid-solid transitions determine unidirectional elongation.

This study evaluates the anti-inflammatory and anti-calcification effects of Entelon150(R) in a beagle dog model of bovine pericardium implantation, finding reduced calcium content and inflammation.