S. Kim

The paper develops a whole yeast-based oral vaccine against Eimeria tenella in chickens, showing reduced parasite replication and improved weight gain in vaccinated birds.

This study produces recombinant monomeric human IL-22 and shows it reduces DSS-induced colitis and pro-inflammatory cytokines in mice.

This paper uses an intestine-on-a-chip model to study NL63 coronavirus infection effects on the human intestine and tests antiviral treatments.

This study shows that ETEC's EatA protein degrades the host MUC2 mucin barrier, enabling bacterial access to enterocytes and toxin delivery.

This paper develops a method using clustered gas vesicles and spectral imaging to enable multiplexed ultrasound imaging for visualizing different species of gas vesicles at the single-cell level.

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

This study shows that IPMK in intestinal epithelial cells protects against colitis by regulating tuft cell development and cholinergic signaling.

This study shows that neutrophil-epithelial interactions enhance SARS-CoV-2 infectivity and pro-inflammatory responses in airway epithelium.

This paper identifies ONG41008 as a TGFβ biogenesis inhibitor with potent anti-fibrotic and anti-inflammatory effects in IPF and inflammatory models.

DEEP-MAP uses deep learning and multi-day microscopy data to predict cell fate dynamics in hPSCs without cell state reporters.

This study uses molecular dynamics and experiments to analyze how mutations in SARS-CoV-2 variants affect their binding to ACE2, identifying which variants are more contagious.

This study develops a strategy using solubility enhancers to produce soluble and bioactive human enterokinase in bacteria.

This study shows that capicua (CIC) regulates thymic T cell development by controlling positive and negative selection and TCR signaling, preventing autoimmunity.

The paper extends CHARMM-GUI Membrane Builder to model and simulate lipid nanoparticles with ionizable cationic lipids and PEGylated lipids, showing how PEG-lipids affect membrane structure and dynamics.

This study identifies unique nuclear import and chromatin engagement mechanisms of AR-V7 in castrate-resistant prostate cancer, suggesting a Hit-and-Run transcriptional mode.

This study investigates the interaction dynamics between Rc-PYP and PBP, revealing a novel photochromic UV sensor mechanism and its potential use in optogenetics.

ONG41008 induces senescence and kills fibrotic and cancer cells without harming normal cells, suggesting it could treat fibrotic and tumorigenic diseases.

This study compares retinal organoid differentiation speed between rhesus macaque and human stem cells, finding NHP-derived organoids develop faster.

This paper investigates how the geometry of synthetic TCR agonists affects T cell activation, finding that ligand height, not epitope, determines potency.

This paper introduces a mean shift algorithm for drift correction in single molecule localization microscopy, improving accuracy in 2D and 3D imaging.

The study identifies NMD-mediated degradation of BrFLC2 mRNA as the cause of early flowering in oilseed-type Brassica rapa LP08 plants.

The paper develops a classification system to identify PPARγ ligands and categorize chemicals as white or brite adipogens using RNA-Seq and lipid accumulation data.

This study identifies drug-induced secretome fucosylation as a mechanism of resistance to targeted therapies across multiple cancers.

This study characterizes triolein's behavior in bilayer membranes and proposes a model for its role in lipid droplet biogenesis through membrane curvature induction.

This study identifies molecular interfaces that mediate EphA2 receptor assembly and distinguishes between canonical and noncanonical signaling pathways.

The paper evaluates the effectiveness of TMPRSS2 and RdRp inhibitors against SARS-CoV-2 variants B.1.1.7 and B.1.351, finding they are equally effective as against the original isolate.

This study shows that optimal mechanical noise and boundary tension in zebrafish embryos ensure robust somite formation and body segmentation.

This study identifies PGE2 production via COX-2 as a cytosol-dependent innate immune response critical for CD8+ T-cell priming against L. monocytogenes.

This paper develops a GelMAL hydrogel for encapsulating stem cells with tunable properties and cleavable crosslinks, preserving stem cell markers.