S. Mukherjee

This study presents cryoEM structures of human pannexin 1 and 3 isoforms, revealing structural differences and how a congenital mutation affects channel properties.

This paper identifies LPD-3 as a conserved megaprotein critical for lipid trafficking between ER and PM, essential for cold resilience in C. elegans and other species.

The paper analyzes gut microbial relationships in wild baboons and finds that microbial correlations are largely universal across hosts, with positive correlations dominated by shared patterns.

This study determines the structure of LRRC8A:C channels and shows how lipid interactions regulate their gating and assembly.

This paper introduces a method using ion mobility on the timsTOF Pro to separate glycopeptides from non-modified peptides, improving glycoproteomics analysis of complex samples.

The paper establishes the near-atomic molecular architecture of the cytoplasmic face of the human nuclear pore complex using interdisciplinary methods.

This paper identifies SidI, a Legionella toxin that mimics tRNA, glycosylates the translation machinery, and triggers a ribotoxic stress response leading to cell death.

This study investigates the fetal lung immune response to intra-uterine inflammation in Rhesus macaques, finding a rapid myeloid cell activation and cytokine-driven inflammation.

This study uses CRISPR screens to identify factors regulating wild-type and mutant p53 stability, finding distinct regulators for different p53 mutants and their implications in cancer.

SCPA identifies novel pathways in early T cell activation using scRNA-seq data, revealing unexpected regulatory mechanisms like type I interferon and arachidonic acid metabolism.

This study shows that chromatin acetylation overrides substrate stiffness effects on hMSCs phenotype and lineage specification by reprogramming mechanoresponse and fate decisions.

The paper demonstrates that proteins and polypeptides can form liquid condensates under high intermolecular interaction conditions, showing that LLPS is a common state across diverse molecular structures.

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

This study shows that shared diffusible biofilm matrix proteins in Vibrio cholerae are susceptible to cheater exploitation, and their evolutionary stability depends on spatial structure, sharing mechanisms, and environmental flow conditions.

This study examines gut microbiome dynamics in wild baboons, finding that microbial dynamics are largely idiosyncratic despite shared environments, with host-specific factors explaining most variation.

The paper shows NAD precursors cycle between host tissues and the gut microbiome to maintain NAD homeostasis.

This study investigates the spatiotemporal solidification of α-synuclein within liquid droplets, showing how solid-like cores form and propagate during droplet aging and fusion.

The paper uses genomic data to reassess the phylogenetic status of the Forest Owlet, finding it as an early split from the Athene clade but sister to other Athene species.

The paper tests personal care products' ability to inactivate SARS-CoV-2 variants and finds they remain effective despite mutations that reduce antibody neutralization.

The paper uses an integrative approach to study mosquito dynamics in urban areas, finding differences in people's experiences with mosquitoes despite no difference in abundance.

This study evaluates the regeneration capacity of size-dependent micro-tissue scaffolds derived from Capra ear cartilage for cartilage defect treatment in rabbits.

This study evaluates CPC-containing mouthwashes' virucidal activity against SARS-CoV-2 variants, showing significant inactivation even in the presence of human saliva.

SINATRA Pro identifies topological differences between protein structures from molecular dynamics simulations, revealing both known and novel biophysical signatures with improved resolution.

The paper demonstrates a FRET-FLIM platform for analyzing cAMP dynamics in HeLa cells, finding that PDE3A and PDE10A significantly slow cAMP decay.

The paper develops NCodR, an SVM classifier that distinguishes seven classes of non-coding RNAs in plants using sequence and structure features, achieving ~91% average F1 score.

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

This study compares the efficacy of three THRβ agonists in modulating gene expression related to cholesterol and fatty acid metabolism in human and rat models.

This study identifies IgG3 subclass {beta}1AR autoantibodies as unique modulators of {beta}1AR signaling, biasing toward G-protein-independent ERK activation and altering {beta}-blocker responses.

This study shows insulin impairs β2AR function via GRK2 and PP2A inhibition, with PI3Kγ regulating PP2A to sustain β2AR phosphorylation.

The paper isolates plant growth-promoting bacteria from legume nodules in Botswana soils, identifying drought-tolerant species and noting differences in microbial composition between soil and nodule microbiomes.