S. Sengupta

Cell lineage as a predictor of immune response in neuroblastoma

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

TRIPLE-NEGATIVE BREAST CANCER CELLS RECRUIT NEUTROPHILS BY SECRETING TGF-β AND CXCR2 LIGANDS

This study identifies that TNBC cells recruit neutrophils by secreting TGF-β and CXCR2 ligands, promoting tumor progression.

A high throughput lipidomics method using scheduled multiple reaction monitoring

This paper introduces a high-throughput lipidomics method using scheduled multiple reaction monitoring to detect over 1000 lipid species, including structural isomers, and identifies changes in lipid composition due to Vitamin B12 deficiency.

The impact of multifactorial stress combination on plant growth and survival

This study investigates how multifactorial stress combinations affect plant growth and survival, finding that while individual stresses have minimal impact, their combination is detrimental.

Nanotube mediated cell-to-cell communication and cannibalism in Halobacillus sp. GSS1 isolated from Sundarbans, India: A cryptic story of survival under nutrient-limiting condition

This paper reports nanotube-mediated cell-to-cell communication and cannibalism in Halobacillus sp. GSS1 under nutrient-limiting conditions, supported by the presence of the ymdB gene.

The impact of water deficit and heat stress combination on the molecular response, physiology and seed production of soybean

This study examines how soybean genotypes respond to combined water deficit and heat stress, finding that heat tolerance does not ensure tolerance to the combined stress, with reduced seed production observed in one genotype under the stress combination.

Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro

This study identifies three phases of hepatocyte dedifferentiation in culture through RNA-seq and ATAC-seq, revealing rapid chromatin changes and fetal gene activation.

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in murine coronavirus-induced neuroinflammation

This paper investigates the role of MMPs and TIMP-1 in MHV-induced neuroinflammation, showing their involvement in inflammation and potential as therapeutic targets.

Dynamics of the COVID -19 Related Publications

This paper analyzes the dynamics of COVID-19 related publications across PubMed, Elsevier, and ResearchGate, finding rapid growth in publication rates and geographic author distribution.

How strategy environment and wealth shape altruistic behaviour: Cooperation rules affecting wealth distribution in dynamic networks

The paper introduces a decision heuristic that links cooperation and wealth distribution in dynamic networks, showing that final cooperation levels depend on strategy environment influence but not network restructuring.

Emergence of ribozyme and tRNA-like structures from mineral-rich muddy pools on prebiotic earth

This study models the emergence of ribozyme and tRNA-like structures from prebiotic environments through non-enzymatic polymerization and hydrolysis processes.

Imaging-Genomics Study Of Head-Neck Squamous Cell Carcinoma: Associations Between Radiomic Phenotypes And Genomic Mechanisms Via Integration Of TCGA And TCIA

This study integrates radiomic and genomic data from HNSCC patients to find associations between imaging features and genomic biomarkers, achieving moderate predictive accuracy for HPV and TP53 mutation status.

Non-affine displacements encode collective conformational fluctuations in proteins

The paper identifies non-affine displacements as key to resolving the free energy landscape of macromolecules using time-structured independent component analysis and Markov state models.

PRMT5 in T helper lymphocytes is essential for cholesterol biosynthesis-mediated Th17 responses and autoimmunity

This study shows PRMT5 is essential for Th17 differentiation and autoimmunity by enhancing cholesterol biosynthesis and ROR-gamma t activation.

SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1)

This study identifies SLC7A5 (LAT1) as a contributor to endocrine resistance in ER+ breast cancer by showing its role in metabolic reprogramming and growth suppression upon inhibition.

Ncl1 mediated metabolic rewiring is critical during metabolic stress

The paper shows that Ncl1 mediates metabolic rewiring in yeast under cysteine excess by linking leucine metabolism to translational control and TCA cycle function.

Development of Human Neuroblastomas in Mouse-Human Neural Crest Chimeras

This study develops a mouse-human neural crest chimera model to study human neuroblastoma development and immune interactions in vivo.

Specific cholesterol binding drives drastic structural alterations in Apolipoprotein A1

This study identifies specific cholesterol binding sites in ApoA1 that drive structural changes from closed to open conformations, revealing a mechanism for cholesterol sequestration.

The evolutionary history of 2,658 cancers

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.

Circadian control of lung inflammation in influenza infection

This study shows that circadian rhythms affect lung inflammation during influenza infection by influencing immune cell composition rather than viral replication.

The Evolution of Antibiotic Production Rate in a Spatial Model of Bacterial Competition

The paper shows that antibiotic production rate evolves to an intermediate level in a spatial model of bacterial competition, allowing coexistence of producers, non-producers, and sensitive cells, with resistant mutants coexisting under specific growth conditions.

On identifying collective displacements in apo-proteins that reveal eventual binding pathways

The paper identifies collective displacements in apo-proteins that correlate with binding pathways without requiring actual binding events.

Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3

This study shows that STAT3 regulates Jmjd3, a histone demethylase, to maintain repression of differentiation genes in glioblastoma stem cells.