S. Wang

This study shows that C. elegans uses mitochondrial surveillance systems and the AMPK pathway to trigger innate immune responses against bacterial pathogens through non-PRR patterns.

This study shows baricitinib reduces lung inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques without affecting viral shedding or immune responses.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This study uses eukaryotic fossils to date the divergence times of Alphaproteobacteria, suggesting their origin ~1900 Ma and revisiting previous assumptions about bacterial evolution timelines.

This study benchmarks seven single-cell RNA-seq methods for immune cell profiling, finding that 10x Genomics 5 v1 and 3 v3 show higher sensitivity and fewer drop-out events.

This study uses single-cell RNA-seq and TCR sequencing to analyze CMV-reactivated CD4+ T cell subsets, revealing their heterogeneity, functional roles, and interactions.

This study reveals how phosphorylation and Ca2+ modulate the SERCA-PLN complex through structural changes that enhance Ca2+ transport.

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

This study investigates the impact of Giardia infection on gut microbiome structure in dogs and children, finding significant microbiome remodeling associated with infection.

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

This paper develops membrane nanoparticles from ACE2-rich cells that effectively block SARS-CoV-2 infection by trapping the viral S1 protein and inhibiting its interaction with host cells.

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

This study investigates how anionic amino acids in Dispersin B affect PNAG substrate recognition and hydrolysis, showing that D147 enhances catalytic activity with cationic PNAG.

This paper introduces BO-CNN, a neural network that detects cell death in live microscopy with 96% accuracy, faster than previous methods and without requiring stains or dyes.

This study performs a time-course transcriptome analysis of lettuce achenes to identify gene expression patterns and molecular mechanisms during achene development.

The paper examines the genomic bases of ecological diversification in core landbirds, identifying adaptive enhancements in diet and vision related to their lifestyles.

The paper investigates how a mutation in Staphylococcus aureus dihydrofolate reductase affects antifolate resistance and NADPH isomerism through chiral evasion mechanisms.

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

The paper reports the first natural SARS-CoV-2 infections in tigers and lions at the Bronx Zoo, identifying two distinct viral strains and suggesting human-to-animal transmission.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This paper uses cryo-EM to show how SARS-CoV-2 spike protein undergoes pH-dependent structural changes that affect ACE2 binding and antibody evasion.

This study identifies potent human neutralizing antibodies against SARS-CoV-2 from convalescent patients, with some showing high efficacy in blocking viral entry.

This study shows luteolin alters BMDM polarization by modulating STAT1/6 pathways, reducing pro-inflammatory factors and increasing anti-inflammatory ones.

This study shows PKCε is required for KRAS-driven lung tumorigenesis and identifies it as a potential therapeutic target.

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.