S. Wang

This study determines the cryo-EM structures of Cas12f to elucidate its dimerization-dependent mechanism for DNA cleavage and substrate recognition.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

This study finds that the rs3842753 C allele is associated with higher INS mRNA and ER stress in beta cells, suggesting a link between genetic variation and beta cell dysfunction in type 1 diabetes.

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

This study shows that A-to-I RNA editing in Xanthomonas oryzae enhances iron uptake by modifying the xfeA gene, improving bacterial competitiveness in iron-limited environments.

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

This study identifies Cwl0971 as a peptidoglycan hydrolase in C. difficile that affects autolysis, toxin release, sporulation, and pathogenicity.

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This study shows that deleting Letmd1 in mice causes mitochondrial dysfunction in brown adipose tissue, leading to thermogenesis disruption and metabolic disorders.

This paper demonstrates that hydrogel-coating enhances the in vivo stability of electrochemical aptamer-based biosensors without compromising detection performance.

This study identifies LsAP2 as a transcription factor regulating seed shape in lettuce, showing its role in seed development and dispersal through interactions with LsBP and involvement in brassinosteroid pathways.

This study shows that cannabidiol (CBD) reduces pulmonary arterial hypertension by improving mitochondrial function and reducing oxidative stress in vascular smooth muscle cells.

This study uses a Lotka-Volterra model to show that biodiversity required for ecosystem functioning increases with spatial or temporal scale, especially when environmental autocorrelation is low.

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

The paper uses single-cell multi-omics to analyze HCC cell lines, identifying metastasis potential heterogeneity and a hypoxic subgroup with poor prognosis.

The paper examines how TCRB repertoire features change with CD4+ T cell differentiation and finds that public clones decrease in differentiated subsets, reducing antigen specificity.

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

This study shows that Polo-like kinase 1 directly controls microtubule-nucleating sites on centrosomes, independent of centrosome size, and is critical for spindle assembly.

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

The paper investigates the opposing roles of retromer and Rab11 in regulating EV cargo traffic at presynaptic terminals in Drosophila, showing they balance cargo loading and removal.

The paper identifies a suboptimal-health gum state (SoH) during experimental gingivitis, characterized by microbiome and metabolite changes similar to periodontitis.

The paper characterizes a clinical Enterobacter hormaechei strain co-carrying blaNDM-1, blaIMP-4, and mcr-9.1, highlighting the convergence of resistance genes in an epidemic clone.

This study shows that ER chaperones BiP and Grp94 regulate proIGF2 folding and oligomerization, with BiP suppressing and Grp94 enhancing oligomerization under different ATP/ADP conditions.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

This study shows that HER2/HER3 signaling and FOXA1 deacetylation drive ER-independent growth in hormone-resistant breast tumors by altering FOXA1 chromatin binding and function.