S. Wang

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study shows immune selection pressure in pancreatic cancer drives myeloid mimicry and immune evasion, which can be counteracted by JAK/STAT pathway inhibition to enhance immunotherapy.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This paper develops a nanoparticle platform for displaying trimeric antigens, showing that SARS-CoV-2 spike-LuS nanoparticles induce 25-fold higher neutralizing responses than spike alone.

This study identifies NTF3 as a fat-derived neurotrophic factor that regulates sympathetic innervation and thermogenesis in adipose tissue, influencing energy metabolism and obesity.

This paper introduces a method to site-specifically incorporate citrulline into proteins in mammalian cells and demonstrates its utility by showing reduced activity of modified PAD4 variants.

This study shows IGPR-1 activates AMPK, linking cell adhesion to autophagy through phosphorylation of ULK1 and Beclin-1, and identifies IKKβ as a key kinase in this pathway.

This study reconstructs the three-dimensional vasculature of Anaxagorea carpels, finding a radiosymmetrical pattern consistent with the Unifying Theory of carpel origin.

The paper identifies three microbial life strategies in soil that respond differently to snowmelt, influencing nitrogen availability during and after winter.

This study shows that EphA2 overexpression in NSCLC tumors reduces T cell infiltration and increases myeloid suppressor cells, promoting immune evasion.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

This study investigates how slime-like and Velcro-like interactions between sialic acid and mannose residues in N-glycan shields on viruses influence self-adhesion and aggregation.

The paper investigates whether tinamou egg coloration serves as a mating signal and whether its diversification is driven by reinforcement, finding support for both predictions.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

The paper investigates how HetR controls gene expression from DIF1 motif promoters during heterocyst differentiation, showing dependence on HetZ and modulation by PatU3.

This study quantifies the Zn uptake and distribution requirements needed to achieve high grain Zn concentration in high-yield wheat on low-Zn calcareous soils.

The paper identifies mitonuclear co-adaptation in warblers by showing a chromosome 5 region associated with mtDNA haplotypes and climate-related selection.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

This study identifies MeSSII's role in cassava starch biosynthesis by forming protein complexes with other enzymes, affecting amylose and amylopectin synthesis.

This study identifies a unique 'fore-mid' four-legged walking pattern in Xya sichuanensis, highlighting physiological and behavioral adaptations for survival in its environment.

This study shows that rhesus macaques infected with SARS-CoV-2 are protected from reinfection during early recovery, likely due to enhanced neutralizing antibodies.

This study shows that SARS-CoV-2 can cause mild COVID-19 in rhesus macaques through conjunctival inoculation, with distinct viral dispersion patterns compared to intratracheal inoculation.

The paper quantifies global forest modification, finding 40.5% of remaining forests have high ecosystem integrity, mostly in specific regions, and highlights the need for policies to protect these areas.

This study identifies a non-canonical Notch1 pathway that represses SIRT1 to drive tumor initiation and chemoresistance in breast cancer stem cells.

This study identifies a non-canonical histone acetyltransferase in CYC/TB1-like proteins that regulates plant architecture by modifying histone H3 and activating gene expression.

The paper describes a new small-bodied troodontid dinosaur from the Upper Cretaceous of Inner Mongolia and confirms its phylogenetic position through analysis.

This study analyzes HTNV genetic diversity and evolution in China and neighboring regions, identifying phylogroups, recombination events, and geographic clustering patterns.

This paper develops a UPLC-MS method to simultaneously quantify seven flavonol glycosides and terpene lactones in Ginkgo biloba tablets, showing good precision and recovery.