S. Wang

The paper shows that aged microbiota causes leaky gut and inflammation by reducing butyrate and FFAR2/3, which weakens mucin barriers.

This paper develops a CRISPRi/a approach to reactivate FOXP3 and silence XIST from XCI in human breast cancer cells, showing enhanced epigenetic changes and therapeutic potential.

The paper predicts conserved T-cell epitopes in SARS-CoV-2 variants using computational methods to identify antigenic peptides that could be used in vaccines.

The paper identifies two circRNAs whose m6A methylation synergistically promotes pulmonary fibrosis by targeting eIF4A3, mediated by METTL3.

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.

This study examines how neo-sex chromosome evolution creates sex-dependent asymmetrical introgression barriers in a hybrid swarm of Drosophila species.

This study uses phylogenomic analysis to estimate the origin of anammox bacteria around the Great Oxidation Event, linking oxygen rise to their evolution.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

This study models the integrated contractile ring and septation system in fission yeast, showing mutual stabilization between the two processes.

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This paper introduces a plasmonic microscope technique for 3D tracking of tethered particles with sub-nanometer axial precision, enabling study of single-molecule dynamics and interactions.

The paper identifies consistently expressed genes in pancreatic ductal adenocarcinoma (PDAC) to prioritize therapeutic targets and biomarkers.

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

This study shows that non-neutralizing antibodies targeting HIV-1 envelope regions reduce mucosal infection and virus burden in humanized mice through Fc-mediated effector functions.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

This study investigates the preventive and therapeutic effects of R-salbutamol, S-salbutamol, and their racemic mixture in a mouse model of LPS-induced sepsis, finding R-salbutamol improves survival and lung function while S-salbutamol worsens outcomes.

This study shows that Pseudomonas aeruginosa induces acute lung injury in mice through its LasB protease, causing hemorrhagic diffuse alveolar damage and hyaline membranes.

This study shows that FliW and CsrA regulate flagellin (FliC) synthesis in C. difficile R20291, affecting virulence and physiology through a mechanism similar to the 'FliW-CsrA-Hag' switch in B. subtilis.

This study determines the structure of DWORF and shows that a kink caused by Pro15 enables its unique activation of SERCA.

This study isolates a temperate Siphoviridae bacteriophage from a Siberian tiger that enhances MRSA virulence through gene upregulation without carrying virulence or resistance genes.

This study measures contractile ring tension in fission yeast and identifies Myo2 and Myp2 as key contributors to force generation and ring organization.

This study develops a far-red probe and microfluidic platform to image live erythrocyte membranes at the single-molecule level, enabling high-throughput super-resolution and tracking.

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

The paper introduces EEIH, a method using hypertonicity to induce endosomal explosion for improved chitosan-mediated DNA delivery.