S. Wang

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

The paper designs and produces molecular probes for SARS-CoV-2 variants to assess immune responses and isolate neutralizing antibodies.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

The paper shows host APOBEC3A, APOBEC1, and APOBEC3G edit SARS-CoV-2 RNA, promoting viral replication and suggesting APOBEC-mediated mutations contribute to viral evolution and new strain emergence.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

The paper digitally reconstructs pectoral girdles of two Early Cretaceous birds, revealing morphological features and their implications for early flight evolution.

This study evaluates the biodistribution of scAAV9-CB-GFP in cynomolgus macaques after intrathecal administration, showing systemic spread and limited brain neuronal transduction.

This study uses artificial selection on H. axyridis to investigate how invasion syndromes evolve, finding that selecting on age at first reproduction leads to more widespread phenotypic changes than selecting on body mass.

This study isolates and characterizes Cryptococcus neoformans capsule polysaccharides using physical and enzymatic methods, revealing that the capsule is assembled from smaller polymers added distally.

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

The paper shows that age-induced P-bodies in yeast shorten lifespan and are detrimental, with cytosol acidification exacerbating this effect.

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

The paper identifies GbNGT1, an N-glucosyltransferase that catalyzes IAA and IAA-amino acid glucosylation, completing the auxin metabolic pathway.

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

The paper identifies SeASF1 and SeH4 as regulators of the PI3K/AKT pathway in filamentous ascomycete, influencing sexual and asexual development through interactions with SeDJ-1 and SePI3K.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

This study uses single-cell RNA sequencing to show heat shock proteins promote BCC growth in response to WNT5A-mediated inflammatory signals from the tumor microenvironment.

This study compares Exo1DA/DA mice with nuclease-dead EXO1 to Exo1-/- and Exo1+/+ mice to show EXO1 has both enzymatic and scaffolding roles in DNA repair, immune response, and tumor suppression.

The paper identifies non-coding mRNAs localized to focal adhesions, showing they function as scaffolds to maintain FA structure and function through RNA binding protein G3BP1.

The paper examines how lateral diffusion of mitochondrial TOM-CC proteins correlates with channel permeability states and mechanosensitive properties.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study shows drought reduces sucrose transport from cottonseed coat to fiber and disrupts sucrose allocation, leading to decreased cellulose synthesis and fiber strength.

This study identifies specific HA mutations in H9N2 avian influenza virus that influence antigenic variation and immune escape from vaccine antibodies.

The paper demonstrates a strategy to engineer plant immune receptors to recognize pathogen effectors by linking effector-dependent degradation to receptor function, resulting in SAP05-dependent resistance in Arabidopsis.

This study identifies genomic diversity and degradation pathways for N,N-dimethylformamide (DMF) by analyzing 20,762 genomes, revealing plasmid-mediated degradation and anaerobic potential for methane production.

This study compares two methods for isolating plant extracellular vesicles and recommends a detailed protocol for Arabidopsis thaliana, including differential ultracentrifugation and immunoaffinity capture for purification.

This study identifies on-target point mutations caused by CRISPR-Cas9 in yeast, showing sequence dependence and involvement of NHEJ components.

This study uses smFRET to examine real-time conformational dynamics of the hHv1 voltage sensor under different voltage and pH conditions, revealing that gating is determined by conformational distributions rather than transitions between resting and activated states.