S. Wang

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

This paper introduces a framework to quantify both aggregate and compositional variability in metacommunities across space and time, identifying four scenarios based on spatial synchrony.

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

This study uses multiplexed 3D imaging and machine learning to analyze colorectal cancer morphology and immune interactions, revealing molecular gradients and cell state transitions.

The paper identifies an allele of WRR4A in Arabidopsis that confers resistance to a virulent isolate of Albugo candida but reduces resistance to other effectors.

This study identifies PRSS2 as a factor that represses Tsp-1 in the tumor microenvironment by binding to LRP1, promoting tumor growth.

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

The paper investigates how prolonged insulin exposure affects muscle cells, finding that reduced insulin receptor expression contributes to insulin resistance.

The paper observes actomyosin contractile instability in isolated cytokinetic rings and shows myosin II turnover prevents catastrophic aggregation and fracture.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This study uses PTR-TOF-MS to analyze microbial volatile compounds during simulated snowmelt, revealing metabolic responses and interactions in soil microbiomes.

Analysis of multiple tmk mutants reveals key roles of TMKs in plant development, including organogenesis, leaf size, fertility, and selfing population defects.

This study uses single-cell transcriptomics to show hyperinsulinemia affects pancreatic cancer development and immune microenvironment by altering immune cell pathways and reducing pre-cancerous lesions.

The paper presents an AI method to predict SARS-CoV-2 variant binding affinity trends using atomistic simulations with high accuracy and reduced simulation time.

The paper analyzes metagenomic data from microbial communities to identify strategies underlying xenobiotic degradation and their ecological interactions.

This study develops and evaluates two multi-epitope vaccines against H. pylori using computer-aided design, showing they reduce bacterial colonization and stomach damage in infected mice.

The paper investigates syncytia formation between SARS-CoV-2 infected and ACE2-expressing cells, finding that it leads to pyroptosis via Caspase-9 and GSDME activation, contributing to severe COVID-19 inflammation.

This study uses cryo-EM to reveal the mechanism of TRiC/CCT ring assembly in yeast, showing subunit-specific roles and ATP-driven assembly dynamics.

The paper develops fluorescent probes to visualize SARM1 activation and identifies a nisoldipine derivative as a SARM1 inhibitor that protects axons from degeneration.

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

This study identifies OsNLP3 as a key regulator of nitrogen use efficiency and grain yield in rice under nitrate-sufficient conditions.

The study examines how opposing genetic dominance in a color gene block affects plumage signals and territorial behavior in hybrid songbirds, linking genetic variation to fitness outcomes.

The paper identifies that CXCL12 at the blood-brain barrier attracts NK cells and ILCs to ischemic brain lesions, improving outcomes after stroke.

This study develops a multi-epitope chimeric antigen (MECU) that generates a broadly reactive antibody response against H. pylori and reduces stomach colonization in mice.

The paper identifies and evaluates strong constitutive promoters in Listeria monocytogenes to enhance foreign antigen expression, finding P18 as the most effective.

This study investigates the structure and function of SslE in E. coli biofilm maturation, showing its role in aggregate formation and exopolysaccharide distribution under acidic conditions.

This study shows that in vitro evolution of SARS-CoV-2 under remdesivir selects for resistant mutations, but these mutations do not spread widely in global variants.

This study investigates the effects of carbon, nitrogen, phosphorus, and potassium on flowering and fruiting of Glycyrrhiza uralensis, finding that higher levels of C, P, and K benefit flower bud differentiation, while excessive N is detrimental, and optimal N and K levels at the filling stage improve seed setting and filling.