S. Yang

The paper shows that circulating phageome in cfDNA reflects bacterial infections and can distinguish between pathogenic and contaminant bacteria.

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

This study uses single-cell RNA-seq to identify intercellular communication drivers of myocardial fibrosis in diabetic mice, highlighting key ligand-receptor interactions and fibroblast subpopulations involved in fibrosis.

This study shows membrane curvature regulates Piezo1 distribution in live cells, with Piezo1 depletion from curved protrusions and enrichment in invaginations, and activation reduces filopodia formation.

The paper examines methane cycling in Arctic thermokarst lagoons and finds that sulfate-driven anaerobic methane oxidation reduces sediment methane concentrations.

This study identifies multiple ParA/MinD ATPases in bacteria that coordinate the positioning of diverse cellular cargos, revealing specificity determinants and indirect regulatory interactions.

This study demonstrates that transfersomes (TLipo) can deliver drugs topically to the middle and inner ear without damaging the tympanic membrane, showing safety and efficacy in vitro and in vivo.

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

The paper reports WAVE Regulatory Complex structures bound to Rac1, revealing how Rac1 binding at the A site activates WRC to drive actin polymerization.

The paper investigates HIV-1 spike protein dynamics using cryo-EM and simulations, showing how tilting exposes the MPER to antibody attack and alters membrane fusion.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

This study identifies the Toll pathway as a key antiviral defense in honey bees, with PGRP-S2 acting as a pattern recognition receptor that interacts with viral proteins to activate the pathway against IAPV infection.

The paper presents high-resolution cryo-EM structures of the full-length human AE1 transporter in various states, revealing substrate binding, inhibition mechanisms, and lipid/sterol binding sites.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This study identifies FOXM1 as a transcription factor that specifies and loads chromatin DNA fragments into extracellular vesicles via an LC3-dependent autophagosome-MVB pathway.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This paper describes a system for recording and analyzing the movement trajectories of a cockroach robot after stimulation.

The paper uses optogenetics to manipulate cGMP levels in megakaryocytes and identifies PDE5 as the main enzyme regulating cGMP.

This study shows that nucleobase clustering in RNA with repeat expansions leads to the formation and hollowing of RNA condensates, contributing to neurodegenerative disease mechanisms.

The paper shows that intracellular pH (pHi) regulates lymphocyte survival and apoptosis through energy metabolism, with low pHi inducing apoptosis and high pHi promoting survival.

The paper constructs a mouse reference gut microbiome (MRGM) and finds significant functional discrepancies between mouse and human gut bacteria of the same genus.

The study reports the first ancient Korean genomes from the Three Kingdoms period, revealing genetic diversity linked to northern Chinese and Japanese Jomon-related ancestry.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.