S. Yang

Urban non-point source pollutants cause microbial community homogenization via increasing deterministic processes

This study shows urban non-point source pollutants homogenize microbial communities by increasing deterministic processes and reducing habitat heterogeneity.

Rapid and visual detection of Schistosoma japonicum circulating nucleic acids by CRISPR-Cas12a

This paper develops a CRISPR-Cas12a-based method for detecting Schistosoma japonicum circulating nucleic acids with high sensitivity and specificity, validated using rabbit serum samples.

Disease-associated gut microbiome and metabolome changes in chronic low back pain patients with bone marrow lesions

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

Phosphorylation modulates estrogen receptor disorder by altering long-range hydrophobic interactions

This study shows phosphorylation at Ser118 of the estrogen receptor's disordered N-terminal domain alters long-range hydrophobic interactions, leading to conformational changes that activate transcriptional function.

Quantifying Amide-Aromatic Interactions at Molecular and Atomic Levels: Experimentally-determined Enthalpic and Entropic Contributions to Interactions of Amide sp2O, N, C and sp3C Unified Atoms with Naphthalene sp2C Atoms in Water

The paper quantifies enthalpic and entropic contributions of amide-aromatic interactions in water, revealing their thermodynamic driving forces and relevance to protein processes.

Effects of sexual dimorphism and estrous cycle on murine Clostridioides difficile infection

This study shows female mice develop more severe Clostridioides difficile infection than males, with estrous cycle phase influencing disease severity and immune response networks.

Engineering in vitro models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials

This study develops synthetic NET-like biomaterials to model CF lung disease, showing they increase mucus viscoelasticity and promote bacterial growth.

Zero-mode waveguide nanowells for single-molecule detection in living cells

This paper demonstrates the use of zero-mode waveguide nanowells to enable single-molecule detection in live cells by reducing observation volume and background fluorescence.

The AusTraits Plant Dictionary

The paper introduces the AusTraits Plant Dictionary to standardize plant trait definitions across databases, improving data integration and usability.

Novel Imaging Guidance for Cholesteatoma Surgery usingTissue Autofluorescence

The paper develops a fluorescence imaging system to distinguish cholesteatoma tissue from middle ear mucosa using autofluorescence properties during surgery.

Immuno-Engineered Mitochondria for Efficient Therapy of Acute Organ Injuries via Modulation of Inflammation and Cell Repair

This study develops nMITO, engineered mitochondria that target inflammation and repair in acute organ injuries, showing efficacy in mouse models of myocardial, liver, and pancreatitis injuries.

Synthetic mucus biomaterials for antimicrobial peptide delivery

This study develops synthetic mucus hydrogels to deliver antimicrobial peptides, showing prolonged activity against Pseudomonas aeruginosa compared to free peptides.

SERPINB3 induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

This study identifies SERPINB3 as a marker for the basal-like/squamous subtype of pancreatic cancer, showing it promotes invasion, metastasis, and metabolic reprogramming.

Rapid molecular phenotypic antimicrobial susceptibility test for Neisseria gonorrhoeae based on propidium monoazide viability PCR

This paper develops a rapid PCR-based method to determine antimicrobial susceptibility of Neisseria gonorrhoeae using propidium monoazide and qPCR, achieving high accuracy in under 30 minutes.

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

Diminishing neuronal acidification by channelrhodopsins with low proton conduction

The paper identifies and characterizes channelrhodopsins with low proton permeability to mitigate neuronal acidification during optogenetic stimulation.

An ULK1/2-PXN mechanotransduction complex suppresses breast cancer cell migration

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.

EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment in Plasmodium male gametogenesis

This study identifies Plasmodium EB1's unique MT-lattice binding role in facilitating spindle-kinetochore lateral attachment during male gametogenesis, essential for proper chromosome segregation and parasite transmission.

Transplantation-based screen uncovers inducers of muscle progenitor cell engraftment across vertebrate species

The paper identifies two lipids that enhance muscle progenitor cell engraftment across zebrafish and mice by activating intracellular calcium flux.

Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer

This study shows Notch signaling in tumor-associated macrophages promotes immunosuppression in pancreatic cancer, and blocking it enhances immune therapy effectiveness.

3D co-culture of macrophages and fibroblasts in a sessile drop chip for unveiling the role of macrophages in skin wound-healing

This study develops a sessile drop chip to create 3D spheroids of fibroblasts and macrophages, showing that M2 macrophages enhance fibroblast proliferation and differentiation in a wound-healing model.

Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans

This study identifies a regulatory axis involving acetylation and ubiquitination of Isw1 in Cryptococcus neoformans that controls multidrug resistance.

Development of a shortwave infrared (SWIR) sinuscope for the detection of cerebrospinal fluid (CSF) leaks

This paper develops a shortwave infrared sinuscope to detect cerebrospinal fluid leaks without contrast agents, showing that CSF has an absorption profile similar to water.

PXN/Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling

This study shows that PXN phase separation drives focal adhesion assembly and integrin signaling through light-inducible manipulation.

Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery

This paper discovers Vibrio natriegens as a microbial platform for efficient formic acid utilization and remodeled it to enhance formate consumption and indigoidine production.

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

Machine Learning Workflow for Single-Cell Antimicrobial Susceptibility Testing of Klebsiella pneumoniae to Meropenem in Sub-Doubling Time

This paper develops a machine learning workflow to predict antimicrobial susceptibility and MIC of Klebsiella pneumoniae to meropenem using single-cell morphological features within sub-doubling time.

RSV-induced Expanded Ciliated Cells Contribute to Bronchial Wall Thickening

This study identifies RSV-induced actin cytoskeleton expansion in ciliated cells as a novel mechanism contributing to bronchial wall thickening in adults.

Microbial diversity and community dynamics in an active, high CO2 subsurface rift ecosystem

The paper investigates microbial diversity and community dynamics in the Eger Rift subsurface, revealing a diverse archaeal population and evidence of anaerobic and acidophilic communities.

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.