S. Zheng

This study identifies EC Rap1B as a key mediator of vascular immunosuppression by promoting T-cell exclusion and tumor growth through regulation of CAMs and NFκB signaling.

The paper introduces a new near-IR fluorophore that enables two-color live-cell SMLM without chemical additives or multiple lasers.

This paper introduces a high-speed 3D phase imaging technique for thick tissues using oblique back-illumination and a z-splitter prism, demonstrating blood flow imaging in chick embryos.

DrugComb updates its repository and analysis tools to include more comprehensive drug combination and monotherapy data, enhanced algorithms, network modeling, and machine learning models for predicting drug sensitivity and synergy.

This study evaluates the antiviral effects of combining remdesivir with repurposed drugs fluoxetine and itraconazole, showing >90% inhibition of SARS-CoV-2 particle production in vitro.

This study identifies Rga6 as a protein that promotes Septin complex localization to the cell cortex in fission yeast, supporting a model of polarized cell growth regulation.

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

This study uses graph theory to analyze how intranasal oxytocin affects frontal brain network properties and links these changes to personality traits.

This study evaluates the cardiac effects of azithromycin and hydroxychloroquine plus azithromycin in guinea pigs, finding QT interval prolongation and cardiac dysfunction with both treatments.

The paper determines the Cryo-EM structures of S-Trimer variants for COVID-19 vaccine development, showing they adopt a tightly closed conformation similar to the full-length S protein.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

This study shows that MT1-MMP regulates tissue homeostasis via a non-proteolytic mechanism by controlling skeletal stem cell differentiation, independent of its proteolytic activity.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

The paper identifies a molecular pore in coronavirus replication organelles that facilitates RNA export to the cytosol, suggesting it as a potential drug target.

This paper develops a molecular clamping assay called ColoScape for early colorectal cancer detection using XNA-mediated qPCR, showing high sensitivity and specificity in clinical samples.

This study shows that polyamine homeostasis in T cells is regulated by de novo synthesis and salvage pathways, affecting proliferation and function, with implications for inflammatory and autoimmune diseases.

This study examines ACE2 receptor usage by SARS-CoV-2 across 14 mammalian species, finding broad receptor activity and implications for zoonotic transmission and animal models.

This study identifies LY6E as a host protein that restricts entry of human coronaviruses, including SARS-CoV-2, through a mechanism distinct from IFITM3.

The paper identifies compounds that reverse nuclear size changes in cancer cell lines and finds they inhibit cell migration and invasion.

This study shows auxin induces TMK1 nanoclustering and lipid nanodomains, which, with microtubule feedback, establish cell polarity in Arabidopsis.

This paper introduces micro-expansion joints to reduce lamella bending during cryo-FIB-milling, improving structural studies of biological samples.

This study identifies circulating bacterial DNA biomarkers for colorectal cancer and adenoma using plasma samples and a random forest model, achieving high accuracy in distinguishing between cancer, adenoma, and healthy controls.

DrugComb provides an open-access portal for drug combination screening data, enabling analysis and prediction of drug synergy using linear regression and chemical fingerprints.

The paper reports the crystal structure of MurJ from E. coli, performs mutagenesis to map functional sites, and identifies co-evolved interactions supporting a rocker-switch model for lipid II transport.

The paper reports the cryo-EM structure of an early pre-60S ribosome intermediate, revealing a half-assembled subunit and key assembly factors involved in rRNA domain joining.

The paper reports cancer-associated transcript fusions in 33 tumor types using TCGA data and provides a resource for accessing the results.

This study shows that extrachromosomal DNA elements and chromosomal alterations in glioblastoma have distinct inheritance patterns and contribute to genomic heterogeneity during tumor evolution.

This paper presents an in vitro platform for rapid nanobody discovery using yeast surface display, demonstrating its application to various antigens including lipid flippase and G protein-coupled receptors.