T. Li

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

This study develops a human endometrial assembloid model that mimics the receptive endometrium during the implantation window, showing structural and molecular features and hormone responsiveness.

This study compares tumor endothelial cells from low-grade and high-grade gliomas, finding they have distinct molecular profiles and functional roles in regulating tumor growth.

The paper develops DICTrank, a comprehensive list of 1318 human drugs ranked by cardiotoxicity risk using FDA labeling, identifying therapeutic categories with high DICT potential.

This study shows that C1q enhances anti-hemagglutinin stem antibody neutralization by blocking viral attachment and expanding the viral escape repertoire.

This study analyzes the nutritional composition and transcriptome of early-stage Japanese eel larvae to understand their nutrient requirements and metabolic pathways.

This study shows Omicron SARS-CoV-2 has higher infectivity and interferon resistance in human nasal tissue compared to Delta, due to changes in Spike protein entry mechanisms.

This study shows that Disulfiram reduces pulmonary fibrosis by reactivating COX-2-mediated PGE2 synthesis in both cell and animal models.

This study shows that VEGFR2 in lymphatic endothelial cells promotes tumor metastasis by regulating lymphatic valve formation and tumor-associated lymphangiogenesis.

The paper quantifies UPF3A and UPF3B expression in mouse tissues, finding UPF3A is ubiquitously expressed, contradicting previous assumptions of limited expression.

The paper sequenced four Zygnematophyceae algal genomes to study signaling network evolution, finding expanded genes for multicellularity and environmental response.

The paper establishes the EstroGene database, which compiles 246 experiments from 136 datasets to analyze estrogen receptor regulomes in breast cancer, revealing diverse temporal, context-dependent, and directional responses.

Lon1 knockout inhibits mitochondrial-encoded gene translation and induces retrograde signaling involving unfolded protein responses.

This study isolates urease-producing bacteria from the cultivation environment of Gracilariopsis lemaneiformis and shows they enhance urea uptake and nitrogen assimilation by the macroalgae.

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

The paper tests SARS-CoV-2 exposure in NYC rats, finding 16.5% seropositive and partial genomes in some, and shows rat susceptibility to Alpha, Delta, and Omicron variants.

This study uses a hybrid agent-based model to show the bone ecosystem promotes multiple myeloma relapse and the evolution of proteasome inhibitor-resistant disease by providing a protective niche for drug-sensitive cells.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

This study compares boric acid and water transport in Arabidopsis NIP I and II proteins, showing differences linked to the ar/R filter's helix 2 amino acid.

The paper addresses critiques of a Transeurasian language and population history study by revising datasets and methods, showing that the original findings remain valid despite objections.

This study shows that neonatal gut bacteria produce serotonin, which promotes immune tolerance by inhibiting mTOR and increasing regulatory T cells.

The paper examines variation in immune perception of microbial features across Rutaceae species, finding that receptor sequences are conserved despite differences in immune responses.

This study shows UPF3A is not required for NMD in mouse pluripotent and somatic cells, and may only weakly promote NMD in some tissues.

This study shows that 17-E2 reduces liver fibrosis in male mice by decreasing collagen synthesis and increasing collagen degradation.

This study identifies how Rabphilin 3A binds the N-peptide of SNAP-25 to enhance SNARE complex assembly, facilitating vesicle exocytosis.

This study identifies a necroptosis-related gene signature (NRGscore) to predict prognosis and therapeutic response in bladder cancer patients using TCGA data.

This study determines the structure of NF-κB p52 homodimer-DNA complexes and shows how DNA conformation and binding kinetics influence transcriptional activation.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

This paper develops an ultra-high-throughput method for microbial single-cell whole genome sequencing to study microbial dark matter and improve metagenomic analysis.