T. Li

This study examines eukaryotic plankton community assembly in the northern South China Sea, finding temperature as a major driver and differential roles of deterministic and stochastic processes across plankton size classes.

The paper uses photo-crosslinking and computational docking to determine the in situ cell-surface conformation of the TCR-CD3 complex, revealing a novel arrangement of CD3 subunits around the TCR.

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

This study shows that hemagglutinin stability affects influenza A virus susceptibility to Arbidol, with stabilized mutants being more sensitive and destabilized ones more resistant.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

The paper presents a dataset supporting labyrinthin as a pan-adenocarcinoma marker through topology, homology, and cell surface localization analyses.

This study investigates how ubiquitination regulates cytoophidium assembly in Schizosaccharomyces pombe by identifying ubiquitination regulators and deubiquitinating enzymes involved in CTPS filamentation.

This study identifies Nla28 target genes in Myxococcus xanthus during starvation, revealing their roles in spore production and stress resistance.

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

This study identifies Vaccinia E5 as a major inhibitor of the cGAS-STING pathway by promoting cGAS degradation through proteasome-dependent ubiquitination.

This paper introduces a deep learning method for single-frame super-resolution microscopy, enabling live-cell imaging at nanometer-scale spatial and millisecond temporal resolutions.

This paper develops nanocrown electrodes for reliable intracellular recording of cardiomyocytes and demonstrates their use in cardiotoxicity screening.

The paper identifies how EPS1, a BAHD acyltransferase, evolved to catalyze a unique lyase reaction in SA biosynthesis in Brassicaceae plants through active site reconfiguration.

This study identifies 97 chemical constituents of Jing-Fu-Kang granules and reveals 531 common targets and 136 pathways involved in its mechanism for cervical spondylosis using mass spectrometry and network pharmacology.

This study identifies MAFB as a key mediator of GC-induced tolerogenesis in dendritic cells, showing its role in epigenomic and transcriptomic remodeling.

The paper identifies key glucosyltransferase and glucuronosyltransferase enzymes in Scutellaria baicalensis and shows how SbUGAT4 contributes to the high accumulation of baicalin in root tissues.

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

TaBln1 negatively regulates wheat resistance to stripe rust by reducing Ca2+ influx through its interaction with TaCaM3 on the plasma membrane.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study shows that knocking out LRIM1 in Anopheles stephensi mosquitoes disrupts microbiome balance, reduces vector competence, and affects reproductive traits.

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

This paper demonstrates that annealing the 70S ribosome at a fast cooling rate synchronizes it into a minimum-energy conformation, enhancing homogeneity and stability for structural analysis.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

This study identifies V-ATPase as a universal regulator of LC3-associated phagocytosis and non-canonical autophagy, showing its role in CASM activation and its disruption by Salmonella SopF.

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

The paper develops a spatial genomics method to map cancer clone structure, character, and evolution across breast cancer progression stages.

This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.