T. Ndung'u

Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

SQuHIVLa: A novel assay for Specific Quantification of inducible HIV-1 reservoir by LAMP

SQuHIVLa quantifies inducible HIV-1 reservoirs in CD4+ T cells using a sensitive and specific RT-LAMP assay, showing high throughput and scalability.

Altered glucose utilization and disrupted mitochondrial homeostasis in CD4+ T cells from HIV-positive women on combination anti-retroviral therapy

This study examines metabolic changes in immune cells of HIV-positive women on antiretroviral therapy, finding altered glucose uptake and increased mitochondrial activity in CD4+ T cells.

Dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of people living with HIV

This study identifies dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of HIV-positive individuals, linked to reduced IL-17A production and increased regulatory molecule expression, contributing to susceptibility to tuberculosis.

Discrepancy between Mtb-specific IFN-γ and IgG responses in HIV-positive people with low CD4 counts.

This study compares Mtb-specific IFN-γ and IgG responses in HIV-positive and HIV-negative individuals, finding higher IgG levels and lower QFT positivity in HIV-positive people with low CD4 counts.

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures

The paper examines HIV-specific CD8+ T-cells in tonsils, finding they exhibit TRM-like exhaustion signatures compared to blood, with differences in natural HIV controllers.

Cysteine dependence in Lactobacillus iners constitutes a novel therapeutic target to modify the vaginal microbiota

This study identifies cysteine dependence in Lactobacillus iners as a therapeutic target to shift vaginal microbiota from L. iners-dominant to L. crispatus-dominant states.

MR1-restricted MAIT cells from the human lung mucosal surface have distinct phenotypic, functional, and transcriptomic features that are preserved in HIV infection

This study identifies distinct phenotypic, functional, and transcriptomic features of MR1-restricted MAIT cells in the human lung mucosa, showing their preservation in HIV infection.

Contrasting inflammatory signatures in peripheral blood and bronchoalveolar cells reveal compartment-specific effects of HIV infection.

This study compares HIV-induced gene expression in peripheral blood and bronchoalveolar cells, revealing distinct inflammatory signatures and compartment-specific effects.

Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection

The paper uses single-cell RNA-sequencing to study immune dynamics in HIV-1 infection, identifying key cellular responses and their temporal progression in untreated individuals.

Low Replication Capacity Virus Is Preferentially Transmitted In Mother-To-Child-Transmission But Not In Adult-To-Adult-Transmission Of HIV-1

The paper compares viral replicative capacity in mother-to-child and adult-to-adult HIV-1 transmission, finding lower replicative capacity in MTCT viruses.

Frequencies of circulating Th1-biased T follicular helper cells in acute HIV-1 infection correlate with the development of HIV-specific antibody responses and lower set point viral load

This study shows that higher frequencies of Tfh1 cells during acute HIV-1 infection correlate with stronger antibody responses and lower viral load.