W. Chen

The paper shows TCF-1 enhances HIV-specific CD8+ T cell expansion and memory properties in elite controllers.

This study shows IL-22 improves liver injury by promoting metabolic reprogramming and mitochondrial function through a signaling pathway involving AMPK, AKT, and mTOR.

This study investigates the role of the dorsal premotor cortex (PMd) in hand gesture preparation in macaques, finding that some neurons are involved in hand shape preparation regardless of visual stimuli or selection strategies.

This paper develops a framework for glomerulus segmentation in kidney histopathology images using Faster R-CNN and U-Net with weakly supervised training.

This study shows anlotinib inhibits drug-resistant colorectal cancer cell proliferation and induces apoptosis by inactivating the PI3K/AKT pathway.

The paper develops and tests a fecal assay to assess bacterial swarming, finding that agar concentration and sample volume significantly affect swarming outcomes.

This study identifies proinsulin self-association as a mechanism driving dominant-negative effects of misfolded proinsulin in MIDY, offering a therapeutic target for enhancing insulin production.

This study shows that GLUT1 inhibition reduces growth of RB1-positive TNBC cells with high glycolytic activity and low OXPHOS, suggesting a therapeutic target in this subset.

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.

This study shows FRA1 modulates CMU proteins' cortical microtubule localization, affecting cellulose and matrix polysaccharide deposition in Arabidopsis.

This study shows that 15-LOX-1 metabolism of LA in PI3P reduces LRP5 membrane levels, inhibits Wnt/β-catenin signaling, and suppresses colorectal tumorigenesis in mice.

This study shows auxin induces TMK1 nanoclustering and lipid nanodomains, which, with microtubule feedback, establish cell polarity in Arabidopsis.

This paper investigates the biosynthesis of formycin A and pyrazofurin A, identifying key enzymes and pathways involved in their C-nucleoside scaffold construction.

This study develops a light-triggered liposome system for spatial and temporal control of CRISPR/Cas9 gene editing, achieving high knockout efficiency in both in vitro and in vivo models.

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.

This paper identifies carbon starvation stress as a trigger for the PprB regulon in Pseudomonas aeruginosa, revealing its role in enhancing biofilm adhesion through BapA and CupE.

The paper uses cryo-EM to study SOPA1's structure and conformational changes upon GTP binding, revealing its unique mechanism in mitochondrial membrane fusion.

The paper creates a gene catalog of bovine rumen microbes, revealing high diversity and function in plant biomass degradation and methane production.

This study shows that xyloglucan homeostasis and microtubule dynamics work together to maintain meristem geometry and phyllotaxis in Arabidopsis.

This study shows that the I232T SNP in FcγRIIB causes structural changes that reduce ligand binding, contributing to SLE pathogenesis.

This study examines T cell function changes in a rat cardiac arrest model after ROSC, finding reduced T cells, increased co-inhibitory molecules, and a shift from Th1 to Th2 responses.

The paper resolves the sex-determination system in Ginkgo biloba, identifying XY chromosomes and five potential sex-determination genes originating ~14 million years ago.

The study investigates imidacloprid resistance in Drosophila melanogaster across different temperatures and finds a polygenic basis with a trade-off against thermotolerance.

This study demonstrates that GII.17 virus-like particles (VLPs) can be produced and show protective potency against NoV GII.17 infection by blocking saliva histo-blood group antigen binding.

This study shows that H. pylori-induced adrenomedullin promotes inflammation in gastritis by enhancing IFN-γ-producing T-cell responses through AKT and STAT3 phosphorylation and IL-12 production.

This study uses metagenomic sequencing to identify pathogens in culture-negative infective endocarditis cases, providing antimicrobial resistance profiles without culturing.

This study shows HDA19 influences cortical cell fate in Arabidopsis roots by interacting with SCARECROW, adding new components to cortical cell specification.

The paper curates a database of virus-host receptor interactions and identifies common features of viral receptors, showing their role in cross-species transmission.

The paper re-examines Na/K pump currents, finding that two-directional charge movement currents become uni-directional under high stimulation, suggesting a single-channel configuration.

The paper investigates SAM-SAM domain interactions in Eph receptors and identifies SAMD5 as a new binding partner, explaining disease-related mutations.