W. Chen

Auxin guides germ cell specification in Arabidopsis anthers

This study shows auxin guides germ cell specification in Arabidopsis anthers by creating a centripetal gradient that is essential for GC initiation and patterning.

Bacterial Swarmers exhibit a Protective Response to Intestinal Stress

This study identifies bacterial swarmers as protective against intestinal inflammation in mice and humans, showing their ability to enrich beneficial gut microbes.

Nudging the N170 forward with prior stimulation - Bridging the gap between N170 and recognition potential

This study shows that manipulating the ISI can transform the N170 into an RP, suggesting that morphology-based classification of ERP components may not be reliable when using forward masks.

Comparative analysis of temporal transcriptome reveals the relationship between pectin degradation and pathogenicity of defoliating Verticillium dahliae to Upland cotton (Gossypium hirsutum)

This study compares the temporal transcriptomes of two Verticillium dahliae strains to identify pectin degradation genes linked to pathogenicity in Upland cotton.

Single-cell RNA-seq of the stromal vascular fraction of adipose tissue reveals lineage-specific changes in cancer-related lymphedema

This study uses single-cell RNA-seq to analyze stromal vascular fraction cells in cancer-related lymphedema, identifying lineage-specific changes and potential therapeutic targets.

Characterization of a clinical Enterobacter hormaechei strain belonging to epidemic clone ST418 co-carrying blaNDM-1, blaIMP-4 and mcr-9.1

The paper characterizes a clinical Enterobacter hormaechei strain co-carrying blaNDM-1, blaIMP-4, and mcr-9.1, highlighting the convergence of resistance genes in an epidemic clone.

Modeling SARS-CoV-2 infection in vitro with a human intestine-on-chip device

This paper develops an intestine-on-chip model to study SARS-CoV-2 infection, showing intestinal damage and immune response similar to human infection.

mRNA translation control by Dhx36 binding to 5' UTR G-quadruplex structures is essential for skeletal muscle stem cell regenerative functions

This study identifies Dhx36 as essential for skeletal muscle stem cell regeneration by regulating mRNA translation through binding and unwinding 5' UTR G-quadruplex structures.

Confinement Discerns Swarmers from Planktonic Bacteria

This study distinguishes swarming from planktonic bacterial motion by confining bacteria in microwells, revealing distinct motion patterns in swarming and planktonic states.

Double-transmembrane domain of SNAREs decelerates the fusion by increasing the protein-lipid mismatch

This study shows that double transmembrane domains in SNAREs slow membrane fusion by increasing protein-lipid mismatch, using in vitro experiments and theoretical analysis.

A novel copper-sensing two-component system for activating Dsb genes in bacteria

The paper identifies a novel copper-sensing two-component system, DsbRS, in Pseudomonas aeruginosa that activates the dsbDEG operon involved in copper resistance.

SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

Diversity and biogeography of Woesearchaeota: A comprehensive analysis of multi-environment data

This study analyzes Woesearchaeota distribution and diversity using 16S rRNA and metagenomic data, revealing their presence in host-associated environments and genomic variation across ecosystems.

Interleukin-22 mediated renal metabolic reprogramming via PFKFB3 to treat kidney injury

This study identifies IL-22's role in renal metabolic reprogramming through PFKFB3 to treat kidney injury in animal models.

Desulfovibrio diazotrophica sp. nov., a sulphate reducing bacterium from the human gut capable of nitrogen fixation

The paper isolates and characterizes a new sulfate-reducing bacterium from the human gut that can fix nitrogen, naming it Desulfovibrio diazotrophica.

Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins

This study examines SARSr-CoV-2 in Malayan pangolins, showing lung infection, vertical transmission, and immune response similarities to COVID-19 in humans.

Phenotype Spectrum reflects Synergies among the Cell Architecture over Stages of the Cell Cycle

The paper investigates the relationship between cell cycle phases and migratory behaviors in NIH 3T3 fibroblasts, showing synergies between cell cycle regulators and migration.

Spliced peptides and cytokine driven changes in the immunopeptidome of melanoma

This study identifies spliced peptides and cytokine-driven changes in the immunopeptidome of melanoma, showing conserved immunogenic peptides across patients.

Functional Exploration of Heterotrimeric Kinesin-II in IFT and Ciliary Length Control in Chlamydomonas

This study investigates the functional differences of kinesin-II in Chlamydomonas, showing that changes in IFT velocity have a limited effect on ciliary length.

Single-cell RNA-seq reveals lineage-specific regulatory changes of fibroblasts and vascular endothelial cells in keloid

This study uses single-cell RNA-seq to analyze keloid tissue and identifies lineage-specific regulatory changes in fibroblasts and vascular endothelial cells, highlighting key pathways and potential therapeutic targets.

A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

Role of combined cell membrane and wall mechanicalproperties regulated by polarity signals in cell budding

This paper develops a 3D model to study how mechanical properties and polarity signals regulate yeast bud formation.

Subnanometer-resolution structure determination in situ by a hybrid subtomogram averaging - single particle cryoEM - workflow

The paper introduces a hybrid workflow combining subtomogram averaging and single-particle cryoEM to improve resolution in structural determination, achieving subnanometer resolution for tobacco mosaic virus and RyR1 ion channel.

Paxillin Promotes ATP-induced Activation of P2X7 Receptor and NLRP3 Inflammasome

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

Traceback of Core Transcription Factors for Soybean Root Growth Maintenance under Water Deficit

The paper identifies core transcription factors regulating root growth in soybean under water deficit by integrating phylogenetic analysis and transcriptome data.

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

Timing of organ initiation is crucial for robust organ size

The paper shows that DRMY1 regulates sepal size in Arabidopsis by controlling organ initiation timing and growth.

Isolation and Characterization of 2019-nCoV-like Coronavirus from Malayan Pangolins

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

New functional identity of the essential inner membrane protein YejM: the cardiolipin translocator is also a metalloenzyme

The paper identifies YejM as a metalloenzyme with phosphatase activity that facilitates cardiolipin translocation, revealing a new functional role in bacterial outer membrane remodeling.

Epithelial organ shape is generated by patterned actomyosin contractility and maintained by the extracellular matrix

The paper investigates how actomyosin contractility and extracellular matrix mechanics shape and maintain epithelial organ morphology in Drosophila wing discs.