W. Li

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

This study identifies a circadian clock control of MRTF-SRF signaling that suppresses beige adipocyte thermogenic recruitment and maintains metabolic homeostasis.

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

The paper quantifies thermodynamic coupling between ligand binding sites in homo-oligomeric proteins using statistical models and native mass spectrometry, revealing large differences in cooperativity.

This study shows that CCR1 activation on respiratory epithelial cells suppresses RSV replication via Gi-mediated inhibition of STAT3 phosphorylation and HSP90 activity, independent of IFN-I.

This study shows that a nutrient-rich diet reprograms intestinal stem cells and lineages, promoting tumorigenesis by altering stem cell function and inducing chronic inflammation.

The paper shows cohesin is essential for meiotic spindle assembly in C. elegans without requiring its role in sister chromatid cohesion.

This paper identifies a small-molecule antagonist targeting the Tudor domain of SMN, disrupting its interaction with RNAP II and mimicking SMN depletion effects.

The paper derives expressions for flux, current, and principal curve in the transition path ensemble using transition path theory and applies them to molecular dynamics simulations of high-dimensional systems.

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

This study develops a sequence-based functional metagenomics approach to discover novel CopA genes in environmental microbiomes, identifying 175 new sequences with functional validation.

This study examines structural and biochemical features of Delta and Kappa SARS-CoV-2 variants, showing increased ACE2 binding and antibody escape, contributing to Delta's dominance.

The paper identifies that the MS2-MCP system can destabilize mRNA and introduces an improved version with minimal mRNA stability perturbation.

This study identifies alveolar macrophage reprogramming by ECP that reduces TGF-β bioavailability and prevents BOS by inhibiting CCR2+ monocyte-driven inflammation.

AtGPA1 regulates low-nitrogen stress response in Arabidopsis by interacting with AtNRT1.4 and AtATG8a, affecting nitrate uptake and autophagy.

This study reports cryo-EM structures of the lentiviral intasome and shows that multivalent interactions are essential for integrase function and virus infectivity.

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

This study reveals that water-bridged interactions facilitate Ca2+ binding and allostery in calmodulin by reducing energy landscape ruggedness and enabling asymmetric EF-hand responses.

This study compares the effects of Cr(III) and Cr(VI) stress on Arabidopsis thaliana, showing Cr(VI) is more toxic due to greater growth inhibition, oxidative stress, and chloroplast damage.

This study identifies a broadly neutralizing antibody fragment and analyzes spike protein mutations in SARS-CoV-2 variants to understand their structural and functional impacts on antibody evasion.

The paper measures nonuniform elastic modulus distribution in Arabidopsis thaliana pavement cell walls using mechanical indentation and computational modeling.

The paper analyzes mutations in the SARS-CoV-2 receptor binding domain to understand their effects on ACE2 and antibody binding in variants of concern.

This study shows that IV BCG vaccination in macaques induces strong IgM responses associated with reduced Mtb bacterial burden and protection.

This study identifies Zfp335 as a transcription factor regulating T cell development by controlling TCRβ expression and cell survival through β-selection-dependent and -independent mechanisms.

This paper optimizes reaction coordinates by maximizing flux in the transition path ensemble, identifying effective coordinates for alanine dipeptide and showing improved committor correlation.

The paper presents a nested PCR protocol for detecting CRISPR-induced indels in hexaploid wheat and evaluates existing genotyping methods for their effectiveness in mutation detection.

This study presents the structure of Odinarchaeota tubulin and shows it forms tubules similar to FtsZ, suggesting it is an evolutionary intermediate between prokaryotic and eukaryotic microtubule-forming proteins.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.