W. Li

This paper develops a host-guest chemistry strategy using cyclodextrins to stabilize GSNO and control NO release, improving its therapeutic and anti-infective applications.

This study identifies multiple factors influencing mitogenomic evolutionary rates in flatworms, with parasitism having the greatest impact despite its monophyletic origin.

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

The paper identifies transgressive and parental dominant gene expression and methylation patterns in Brassica napus hybrids during seed development, linking them to early heterosis mechanisms.

The paper develops a framework to identify areas with high potential for sustainable human-wildlife coexistence by integrating human willingness-to-coexist with habitat suitability models, applied to elephants and rhinos in Maasai Mara.

This study uses single-cell RNA sequencing to show that aging impairs intestinal stem cell maturation, which is reversed by metformin and rapamycin.

This study uses cryo-ET to reveal three distinct actin sub-domains in lamellipodia, including filaments with barbed ends pointing toward the cell center.

This study identifies PlAvh202, an RXLR effector from Peronophythora litchii, which enhances plant susceptibility by destabilizing SAMS and suppressing ethylene production.

The paper identifies HHV-6 reactivation in CAR T cells using single-cell sequencing and links it to clinical neurotoxicity observed in patients.

This study identifies intrinsically disordered regions in BRCA1/BARD1 that mediate chromatin recruitment and ubiquitylation, enhancing DNA damage repair and transcriptional regulation.

This study shows that hypoxia sensing in cardiac macrophages influences monocyte differentiation into inflammatory states after heart injury.

This study identifies an allosteric network in vinculin regulated by talin, showing how force and binding dynamics control focal adhesion formation.

This paper develops a digital frailty index using home-cage video monitoring in mice, showing it correlates with manual scores and age, reducing stress and labor.

This study characterizes a Mycobacterium tuberculosis dipeptidyl peptidase with high thermal stability and shows its potential role in immune modulation.

The paper introduces two quantities, potential energy weighted reactive flux and total rate of change of potential energy, to identify reaction mechanisms in nonequilibrium ensembles and demonstrates their application to alanine peptide transitions.

This study uses phosphoproteomics to analyze metformin signaling in CRC cell lines, revealing heterogeneous responses and identifying potential drug interactions.

This study uses single-cell RNA-seq to identify intercellular communication drivers of myocardial fibrosis in diabetic mice, highlighting key ligand-receptor interactions and fibroblast subpopulations involved in fibrosis.

This study shows that lumpy skin disease virus activates PERK and IRE1 pathways to support its replication, suggesting potential therapeutic targets for poxvirus infections.

This study identifies myosin-X and DAAM1 as key factors promoting chiral growth in adherent filopodia, revealing how actin dynamics drive left-right asymmetry in cellular protrusions.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

The paper discovers and evaluates two fully human antibodies that inhibit NKG2A, an inhibitory receptor on NK and CD8+ T cells, enhancing anti-cancer immune responses.

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

This study shows that Pnpt1 mediates NLRP3 inflammasome activation in macrophages through MAVS and metabolic reprogramming, enhancing IL-1β and IL-18 secretion in sepsis models.

The paper identifies SPTAN1 and RAF1 as genes activated by shear stress during cardiopulmonary bypass, leading to inflammation and cell death through store-operated calcium entry.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study shows that actin cytoskeleton signaling via MRTF/SRF modulates circadian clock entrainment by responding to extracellular matrix cues.

This study identifies DNALI1 as a key protein in sperm development, showing its role in the MEIG1/PACRG complex for cargo transport along the manchette and its involvement in sperm individualization.

This study evaluates a multivalent mRNA vaccine encoding SARS-CoV-2 and SARS-CoV receptor-binding domains, showing it induces cross-neutralizing antibodies against multiple variants in mice.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.