W. Li

This study evaluates the chemical composition, antimicrobial, and antioxidant activities of essential oils from sunflower receptacles, showing their potential as natural preservatives and medicines.

This study expands tumor-specific T cells from pancreatic cancer patients' blood using tumor organoid-immune co-cultures and identifies patient-specific TCRs for immunotherapy.

RAPPID is a homogeneous immunoassay platform using ratiometric bioluminescent sensors for direct in-sample calibration and quantitative detection of biomarkers.

This study isolates two cross-reactive monoclonal antibodies against multiple Betacoronaviruses, identifying a conserved vulnerable site on the spike protein.

This study uses Hi-C to identify structural variations in lung adenocarcinoma tissues, revealing compartment shifts, TADs, and enhancer-promoter loops associated with key genes on chromosome 3.

The paper shows how the MEN signal is transmitted from the cytoplasm to the nucleolus through kinase-mediated phosphorylation in budding yeast.

This paper identifies a human monoclonal antibody, 47D11, that targets a conserved hydrophobic pocket in the SARS-CoV-2 RBD, revealing its structural basis for neutralization and potential therapeutic use.

The paper shows that S and HE proteins co-evolve to balance attachment and release in coronaviruses, with functional interdependence observed in OC43 and HKU1.

This paper improves automated Gleason grading by using image-based patch selection to enhance segmentation accuracy in histopathological slides.

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

This study shows that Mfge8 inhibits human gastric antrum smooth muscle contractions by reducing MYPT1 phosphorylation and LC20 phosphorylation through its interaction with 8β1 integrin.

The study investigates genomic divergence between two Populus species, finding that barriers to gene flow, not natural selection, drive reproductive isolation.

This paper develops potent anti-SARS-CoV-2 DARPin therapeutics with low picomolar neutralization efficacy and reports their protective efficacy in a hamster model.

This study shows that high-dose convalescent plasma or monoclonal antibodies protect hamsters from SARS-CoV-2-induced lower respiratory disease, but lower doses are ineffective.

This study shows SARS-CoV-2 suppresses selenoprotein mRNA expression linked to ferroptosis, ER stress, and DNA synthesis, while increasing IL-6 expression in Vero cells.

This study shows AHP4 negatively regulates Arabidopsis drought response by modulating gene expression related to stress tolerance mechanisms.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

This paper identifies and characterizes the NIC1-locus in tobacco, showing it regulates nicotine biosynthesis through ERF genes that function downstream of NtMYC2 in the JA signaling pathway.

This study uses computational modeling to show that UBIAD1 mutations in Schnyder corneal dystrophy disrupt GGPP binding to HMGCR, increasing structural flexibility and promoting their interaction.

This paper develops a nanoparticle platform for BBB-independent siRNA delivery in TBI, achieving higher brain accumulation and gene silencing through surface chemistry and coating density modulation.

The paper shows that disrupting cell cycle checkpoints can restore DNA damage-induced inflammation and anti-tumor immune responses in cancer cells.

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study compares how HeLa-JW cells respond to fibronectin, galectin-8, and their mixtures, revealing distinct effects on cell spreading, focal adhesions, and filopodia formation.

This study shows that AKAP95 protein condensates regulate splicing and tumorigenesis through their biophysical properties.

This paper introduces a high-throughput microfluidics system for perfusion and validates its use in long-term all-optical electrophysiology of human cells.

The paper identifies Vβ2-specific germline contacts that contribute to a focused T cell response against a parasite-derived peptide presented by H-2Ld, enhancing HIV control.

This study examines how environmental factors and landscape heterogeneity influence genetic structure in wild rice Zizania latifolia across a latitudinal gradient in China.