X. Han

This study shows that even after correcting hyperglycemia, persistent lipotoxicity from arachidonic acid and lysophosphatidylcholine impairs β-cell function in diet-induced obese mice.

This study shows that 25-hydroxycholesterol from microglia alters astrocyte lipid metabolism and ApoE secretion through mechanisms involving LXRs, Abca1, and Cyp7b1.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

This study compares microbial communities in intertidal sands with and without deposit-feeding worms, showing that worms shape subsurface ecosystems by altering microbial abundance and network connectivity.

This study shows that PPAR-γ activation with rosiglitazone reduces oxidative stress and promotes xenograft regeneration in a dental follicle cell model.

This paper introduces RLN, a deep learning method for 3D fluorescence microscopy deconvolution that improves speed, performance, and generalizability compared to existing methods.

The paper uses cryo-EM to reveal cooperative conformational changes in KaiC hexamers that enable switch-like phosphorylation responses.

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

This study investigates how caloric restriction affects adipose tissue and metabolic health, finding that its benefits are sex- and age-dependent in mice and humans.

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

The paper investigates the role of the intrinsically disordered region (IDR) in coronins, showing it fine-tunes oligomerization and actin polymerization through evolutionary conserved patterns.

This paper develops self-powered artificial cell colonies that mimic muscle behavior through actin polymerization and depolymerization, showing reversible deformation and collective contraction.

This study investigates how orthoformimycin inhibits translation elongation by displacing the A-site tRNA and blocking peptide bond formation using X-ray crystallography and kinetic analysis.

This study investigates how cancer affects insulin signaling and glucose transport in different muscle types, finding muscle-specific impairments in insulin response and signaling pathways.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

The paper examines the 13,500-year sedimentary record of Lake Cadagno to study microbial activity and geochemical changes, revealing redox shifts and a deep oxidizing groundwater source impacting organic matter remineralization.

This study shows that soil inoculum origin and amount affect microbiome and plant community development in degraded grasslands over three years.

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

This study compares proteomic profiles of vancomycin-intermediate resistant S. aureus strains to identify differentially expressed proteins associated with vancomycin resistance.

This study develops a high-throughput method to produce functional prototissues that generate nitric oxide, inducing vasodilation in rat blood vessels.

This study shows that the hexapeptide WKYMVm promotes M2 macrophage polarization via the JAK1/STAT6 pathway, enhancing angiogenesis in bone repair.

The paper identifies MK-derived immune-stimulating cells (MDICs) that enhance host defense against bacterial infections by interacting with myeloid cells and producing cytokines.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

The paper tests hypotheses about stomatal size-density scaling in plants using macroevolutionary models and phylogenetic regression on 2408 species, finding support for the stomatal-area increase hypothesis for higher gmax.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.