X. Li

This study shows that three nucleotide analogues inhibit SARS-CoV-2 polymerase by being incorporated and blocking further RNA synthesis.

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.

This study analyzes SARS-CoV-2 genome data to infer its evolution and population demography using phylogenetic and population genetics methods.

This study shows miR-214 reduces pulmonary angiogenesis and alveolarization in BPD by inhibiting PlGF and STAT3 signaling in hyperoxic rat models.

BR-activated BZR1 suppresses ACO1 activity and expression of ACO1 and ACS1a, reducing ethylene production during pear and apple fruit ripening.

This study shows artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression by enhancing autophagy and modulating NF-κB activity.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

This paper develops and validates an LC/MS/MS method to quantify ceramides and dihydroceramides in human serum, revealing unique gestational patterns during pregnancy.

The paper shows PCV2 worsens SS2 infection in PK15 cells through differentially expressed proteins and pathway analysis.

This study presents the structures of human KCC2 and KCC3, including phosphorylation and inhibitor-bound forms, revealing mechanisms of regulation and potential drug targets.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

Endosidin20 inhibits cellulose synthesis by targeting the catalytic site of CESA6, reducing cellulose synthase complex delivery to the plasma membrane.

The paper shows that cell-cell adhesion strength influences tumor growth rates through a pressure-adhesion feedback loop, with an optimal adhesion level maximizing proliferation.

The paper predicts evolutionary changes in floral traits of Brassica rapa under artificial and pollinator selection using a G-matrix, showing predictable responses and genetic covariance effects.

This study shows that mechanical alignment of actin filaments precedes chemical changes during bundle formation in response to tensile force.

This study shows that rats emit distinct volatile organic compound profiles in their breath when exposed to various airborne toxicants, indicating a potential for using breath analysis to monitor air toxicity.

This study evaluates the binding of ritonavir, lopinavir, and darunavir to SARS-CoV-2 proteases using molecular modeling, finding that ritonavir and lopinavir inhibit CEP_C30 more effectively than darunavir inhibits PLVP.

The paper investigates the potential of nucleotide analogues, specifically EPCLUSA, as inhibitors of viral polymerases in coronaviruses like 2019-nCoV, SARS, and MERS.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

The paper analyzes gene expression in poplar phloem and xylem using microarray data and the GPDNN model to identify and study genes related to plant hormones, focusing on auxin response factors.

This study shows that S. thermophilus 19 reduces inflammation in septic mice by remodeling gut microbiota.

This paper solves the crystal structure of the giant panda MHC class I complex, revealing unique features of viral peptide presentation in the bear family and providing insights for vaccine design.

The paper introduces iSCAPE, a system that separates atmospheric particles using electrostatic fields and mineral oil, showing different particle mobility and enrichment based on source and charge.

This study identifies eight distinct evolutionary lineages in the common pheasant, revealing regionally divergent drivers of diversification and suggesting the species should be split into three species.

The study shows that millet-based supplements improve gut microbiota diversity in undernourished pigs more effectively than corn-based supplements.

This study determines the cryo-EM structure of a novel α-synuclein fibril formed by the E46K mutation, showing structural changes and altered stability compared to wild-type fibrils.

This study estimates the economic burden of severe mental disorder in China from 2014-2017 using prevalence-based methods, finding substantial direct and indirect costs.

The paper compares theoretical simulations and experimental data on cell movement in tumor spheroids, revealing distinct subdiffusive and superdiffusive dynamics in core and peripheral cells.