X. Li

This study investigates ligand bias at C5aR1 by comparing C5a and C5apep, showing differential activation of G proteins, βarr recruitment, endocytosis, and ERK1/2 phosphorylation.

The paper identifies Dnmt3aos as a lncRNA regulating Dnmt3a expression and DNA methylation in macrophage polarization, revealing its role in modulating IFN-gamma expression.

This study identifies TIM-1 and endocytic pathways as key mediators of exosome entry and cargo delivery for IFN-α-induced antiviral activity transfer from macrophages to hepatocytes.

This paper shows bacteria enhance mammalian NAD metabolism by using a deamidated biosynthesis pathway, contributing to drug resistance and improving NAD-boosting efficiency.

This study shows that E2-2 and HEB are essential for early lymphoid specification, as their disruption blocks B-cell and T-cell development while leaving other hematopoietic lineages unaffected.

This paper develops an evolutionary model explaining intratumor heterogeneity through unequal allocation of paracrine growth factors, showing it persists only under specific exogenous resource conditions.

This paper develops a platform to multiplex profile single-cell EV secretion, revealing heterogeneity in EV phenotypes and secretion patterns in OSCC cells.

This study identifies and analyzes microbial contaminants in biological laboratories, finding that lab type influences microbial communities more than sampling site, and identifies environmental and human factors as key sources.

The paper identifies MoRgs7 as a GPCR-like receptor in Magnaporthe oryzae that senses hydrophobic surfaces via hydrophobic interactions, couples with Gα subunit MoMagA for endocytosis, and promotes cAMP signaling required for appressorium formation and pathogenicity.

The paper investigates CD8+ T cell infiltration into tumor-cell clusters in TNBC, proposing a chemo-repellent mechanism and ruling out collagen fiber restrictions.

The paper shows dietary fatty acids influence lipid droplet diversity via SEIP-1 enrichment in an ER subdomain in C. elegans and mammalian cells.

The paper presents cryo-EM structures of the human 26S proteasome in seven conformational states during polyubiquitylated protein degradation, revealing dynamic substrate-proteasome interactions and ATP hydrolysis mechanisms.

This study investigates the biosorption of Pb(II) and Zn(II) by Verticillium insectorum J3, finding that it absorbs Pb(II) preferentially and shows enhanced biosorption at higher concentrations.

The paper demonstrates that intron-mediated enhancement significantly boosts circRNA expression and enables translation into detectable proteins, offering a robust method for studying circRNA functions.

This study identifies a deletion in TMPRSS6 associated with reduced hemoglobin and improved blood viscosity in Tibetan pigs adapted to high altitude.

This study screens global microbiomes to identify pathogen-enriched environments using a Local BLASTP method, finding pore-forming RTX toxin and adenylate cyclase Cya as globally prevalent toxins.

The paper develops a workflow for preparing micro/nano-crystals for MicroED, enabling the study of small macromolecular crystals previously unsuitable for this technique.

This study uses computational modeling to show that T2DM alters platelet margination through changes in RBC deformability, platelet size, flow rate, and WBC interactions.

This study clones and characterizes the CD40 ligand in cotton rats, showing its functional activity on dendritic cells and potential utility in immunological research.

The paper investigates speciation mechanisms in mangroves, finding that cycles of isolation and gene flow (MIM) drive speciation between oceanic regions, challenging the traditional model of strict allopatry.

This study shows that transient VEGF-A overexpression in adipose tissue activates the sympathetic nervous system, enhancing lipolysis, browning, and energy expenditure.

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.

CLADES uses machine learning to delimit species from population genetic data, showing accuracy and efficiency compared to existing methods, especially in cases with short divergence times and gene flow.

This study examines the effects of CEPA and 1-MCP on flower bud differentiation in apple trees grafted on different rootstocks, finding CEPA promotes flowering while 1-MCP has no significant effect.

This study shows metformin improves uterine progesterone signaling in PCOS-like rats by reducing PGR and ER expression and correcting gene expression abnormalities.

The paper investigates MATR3's role in neurotoxicity, finding that its RNA binding and localization affect neuronal survival and disease mechanisms.

The paper studies collective cell migration in tumor evolution, finding that growth rate influences the transition from glassy to super-diffusive behavior and reveals super-diffusion's universality in non-equilibrium systems.

This study identifies novel germline V and J alleles in Rhesus macaques by analyzing BCR repertoires and validates them using whole genome sequencing and alignment reference.

The paper identifies a potent and selective ROR1-targeting scFv, R11, and determines its structure bound to ROR1, showing its antitumor activity in vitro and in vivo.

The paper develops a base-resolution m1A profiling method and identifies distinct m1A methylome classes in human nuclear and mitochondrial transcripts, showing functional roles in translation efficiency and mitochondrial mRNA regulation.