X. Li

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

This study shows that SETD2 deficiency disrupts the β-catenin destruction complex, promoting ccRCC formation, and links SETD2-mediated H3K36me3 to Wnt/β-catenin signaling in renal cancer.

This study identifies Rbg1/Tma46 as a heterodimeric GTPase that promotes efficient translation by resolving ribosome pausing and stabilizing mRNAs.

This study shows that phosphorylation of HIM-3, a HORMA domain protein, regulates asymmetric synaptonemal complex disassembly in C. elegans meiosis by modulating its interaction with HTP-1 and HTP-2.

The paper investigates whether pre-existing cutaneous conditions increase SARS-CoV-2 infection risk by examining ACE2 expression and skin barrier function in human and mouse models.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

This study shows IFITM3 inhibits viral fusion by altering membrane curvature and stiffness, with its amphipathic helix playing a key role in these effects.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study evaluates givinostat's efficacy in treating NASH by reducing inflammation and fibrosis in mouse models.

This study develops a non-infectious murine model to study SARS-CoV-2-induced ARDS and CSS, and identifies potential therapeutic agents that alleviate inflammatory symptoms.

The paper shows signal sequences regulate protein translocation and folding in the ER by pausing translocation until chaperones bind, ensuring proper folding and preventing aggregation.

The paper develops REFLECT, a method that maps recurrent co-alteration signatures to drug combinations using multi-omic data, validating its effectiveness across 201 cohorts and 10,392 patients.

The paper uses metabolomics to show that switchgrass has diverse specialized metabolites varying by tissue and ecotype, with saponins being particularly abundant and ecotype-specific.

This study analyzes gut microbiome data from 361 elderly women to explore its association with bone mass loss and bone mineral density.

This study shows that S-enantiomers of chloroquine and hydroxychloroquine are more effective against SARS-CoV-2 and less toxic than their R-enantiomers, suggesting S-HCQ as a better treatment option for COVID-19.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

This paper develops a subject-specific finite element head model with accurate white matter tracts and evaluates its sensitivity to anatomical variability in predicting brain strain during concussive loading.

The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.

The paper shows that EFF-1 induces muscle fusion in C. elegans, causing paralysis and morphological defects, and demonstrates that AFF-1-coated viruses can infect EFF-1-expressing muscles, revealing potential applications in gene therapy and viral-host interactions.

This study shows JAG1-NOTCH4 signaling promotes atherosclerosis by repressing endothelial repair in response to low oscillatory shear stress.

This study identifies mitotic slippage due to defective chromosome attachments as the origin of polyploidy in esophageal adenocarcinoma.

This study identifies heparan sulfate proteoglycans as an attachment factor for SARS-CoV-2 and suggests HS oligosaccharides could inhibit viral binding.

This study introduces a quantitative metric to evaluate therapeutic antibody doses and identifies factors influencing dose selection beyond traditional pharmacokinetics and target binding affinity.

The paper identifies lipid droplet-like structures in gut microbiota from mouse and human samples and establishes a method to study them.

This study tracks zoliflodacin susceptibility trends in Neisseria gonorrhoeae isolates from 2014-2018, showing increasing MICs and resistance mutations, while maintaining overall susceptibility.

The paper designs and analyzes ACE2-derived peptides to inhibit SARS-CoV-2 spike protein binding to hACE2 using molecular dynamics simulations.

This study compares antioxidant enzyme activity, dehydrin expression, and gene expression in two switchgrass cultivars under drought stress to identify markers of drought tolerance.