X. Tian

PG3-Oc restores p53 pathway signaling in mutant-p53 tumors through ATF4 modulation by ERK1/2 and CDK9, inducing p53 effector genes for cell death and tumor suppression.

This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.

This study investigates how gut microbiome-derived short-chain fatty acids (SCFAs) and their receptors FFAR2/FFAR3 regulate lung immune tone through IL-1β expression in mouse and human lung tissues.

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

This study investigates the cardiac electrophysiological effects of hydroxychloroquine and azithromycin, showing they prolong QT intervals and increase arrhythmia risk when combined.

This study develops a SARS-CoV-2 vaccine candidate using virus simulating particles that induces strong neutralizing immune responses with a single dose.

This study identifies SARS-CoV-2 host targets and perturbed proteins in PBMCs from COVID-19 patients, revealing potential virulence factors involved in cytokine storms and disease pathogenesis.

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

This study shows that the SARS-CoV-specific antibody CR3022 binds strongly to 2019-nCoV RBD with a KD of 6.3 nM, while other antibodies targeting the ACE2 site fail to bind, highlighting the importance of RBD differences for cross-reactivity.

This study identifies structural variants in Asian rice and its wild ancestor, finding they are predominantly deleterious and contribute to domestication costs and agronomic trait changes.

This study identifies Cqs2 as the critical determinant for orchestrating the unisexual cycle in Cryptococcus neoformans without requiring the sex-determination program.

This study investigates chunking mechanisms in reading by analyzing lexical decision times and EEG responses to Chinese strings with varying chunk structures, finding that global chunks are processed before local chunks.

The paper shows CDK1 phosphorylates ULK1-ATG13 in mitosis to regulate autophagy and Taxol sensitivity, with implications for cancer therapy.

This study extends the in vivo haploid induction system from diploid maize to hexaploid wheat by knocking out homologous genes, achieving 2%-3% haploid induction with 30%-60% seed setting rate.

This study examines how Plasmodiophora brassicae infection alters the fungal endophyte community in stem mustard roots using sequencing and culture methods, finding reduced diversity and shifts in dominant taxa.

The paper compares soil nematode communities in greenhouses with 2 and 10 years of continuous cropping to reveal changes in community dynamics and factors influencing nematode composition.

This study identifies risk and protective factors for dengue virus infection in Guangdong Province through a case-control study, finding activities in the park, outdoor sports, and poor indoor daylight quality as risk factors, and air-condition use as protective.

This study shows that vitamin A supplementation after neonatal Streptococcus pneumoniae pneumonia reduces allergic asthma in mice by altering CD4+ T cell subsets.

This study shows that Bacillus cereus YL6 promotes growth of soybean, wheat, and Chinese cabbage by solubilizing phosphorus and producing plant hormones, while also colonizing plant roots.

This study shows that CRISPR-Cas12a activates non-specific single-stranded DNA cleavage upon guide RNA-dependent DNA binding, distinguishing it from CRISPR-Cas9.

This study shows that RAF1 mutations in Noonan syndrome cause cardiac hypertrophy through cytokine signaling from endothelial cells, with TNF/IL6 as potential therapeutic targets.

This paper designs synthetic vesicles that exhibit chemotaxis by converting glucose, showing improved brain penetration compared to non-chemotactic systems.