X. Wang

The paper analyzes SARS-CoV-2 genome sequences to show mutation sweeps driven by emerging variants, which may prolong the pandemic and challenge control efforts.

The paper uses molecular dynamics simulations to analyze how three imidazoquinoline agonists selectively bind to TLR7 and TLR8, revealing van der Waals interactions as key to their selectivity.

The paper investigates age-dependent H3K9 acetylation changes in rice flag leaf senescence, finding increased H3K9ac levels correlate with gene expression and identify regulatory networks.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study identifies a non-canonical Hif-1 splice variant in locusts that supports sustained flight by promoting glucose oxidation and redox homeostasis under aerobic conditions.

This study shows that inhibiting Tip60 acetyltransferase with TH1834 improves cardiac function and reduces damage after myocardial infarction in mice.

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

The paper introduces an AuSERP biochip to detect single extracellular vesicle RNA and protein biomarkers for predicting immunotherapy responses in NSCLC patients, showing higher sensitivity than traditional methods.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study shows that total parenteral nutrition (TPN) causes glucose metabolism disorders by altering gut microbiota and its metabolites, as demonstrated through human and mouse models.

The paper describes exceptionally preserved muscle systems in Cambrian cnidarians, providing insights into the evolution of muscle systems in early animals.

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This paper develops a tissue-bioengineering strategy using TSC patient-derived kidney organoids to model rare kidney diseases in vivo and test therapeutic approaches.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

This study identifies a non-metabolic role of nuclear PHGDH in liver cancer by promoting neutrophil recruitment through the PHGDH/cMyc/AF9 axis, suggesting it as a therapeutic target.

This study shows that Esm-1 reduces albuminuria and podocyte injury in diabetic mice, possibly through inhibiting interferon signaling.

This study shows that CD47 cross-dressing via extracellular vesicles inhibits phagocytosis without causing cell death, offering a safer alternative to CD47 overexpression.

This study shows that extracellular fluid flow reduces cellular quiescence depth through physical and biochemical cues, making cells more likely to reenter the cell cycle.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

DeGlyPHER is an ultrasensitive method to analyze viral spike N-glycoforms, assessing glycan occupancy and processing from high-mannose to complex forms at each N-glycosylation site.

This study identifies ten Shaker K+ channel genes in foxtail millet and analyzes their expression under abiotic stresses and ABA treatment, revealing distinct regulation patterns.

This study shows the Nrf2/Keap1 axis is activated by EIAV-Rev, leading to antiviral effects through two mechanisms: enhancing antioxidant defenses and inhibiting Rev-mediated RNA transport.

This study examines mosquito resistance to PBO-synergized pyrethroids and finds that field mosquitoes are resistant despite PBO exposure, due to elevated metabolic enzyme levels and knockdown resistance mutations.

The paper analyzes small RNA expression dynamics in tomato accessions to show how genomic structural variants influence different small RNA classes and their selection pressures during domestication.

This study identifies and characterizes Aeromonas species in farmed loaches from China, finding high prevalence of A. veronii and resistance to multiple antibiotics.

This study shows that TFR1-mediated iron uptake in osteoclasts affects mitochondrial function and cytoskeleton, leading to increased bone mass in female mice.

This study investigates how the chemical structure of VIP amphiphile micelles affects their immunomodulatory properties and identifies a lead formulation with enhanced anti-inflammatory effects.

This paper identifies redox-related protein targets of peroxide antimalarials using chemoproteomics and confirms their impact on redox homeostasis in Plasmodium falciparum.