X. Wang

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

This study compares optic nerve head deformations during adduction, abduction, and IOP elevation in HTG and NTG subjects, finding strain differences in the lamina cribrosa.

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

This study demonstrates retron editing enables efficient precise genome editing in human cells without exogenous donor DNA, achieving up to 10% editing rates at endogenous loci.

Histo-Cloud is a cloud-based tool for whole slide image segmentation that simplifies access for non-experts, demonstrating its use in renal histopathology.

This study presents a chromosome-scale spinach reference genome and resequences 305 accessions to explore evolution, domestication, and genetic basis of agronomic traits.

This study identifies early megakaryocyte lineage-committed progenitors in adult mouse bone marrow and proposes a differentiation model involving intermediate progenitors.

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

The paper identifies a Jurassic fossil as an epiphytic macrolichen, suggesting macrolichen diversity predates the Cenozoic diversification of extant lineages.

This study shows MYC enhances WNT signaling in colorectal cancer cells by repressing DKK3 via miR-92a, creating an oncogenic feedback loop.

This study shows that phage resistance mechanisms in A. baumannii reduce colistin resistance by altering bacterial envelope structure, increasing antibiotic sensitivity.

The paper analyzes transcriptome and metabolome data from plum fruits at different developmental stages to identify pathways and genes associated with fruit color changes.

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

TaBln1 negatively regulates wheat resistance to stripe rust by reducing Ca2+ influx through its interaction with TaCaM3 on the plasma membrane.

This study investigates the tissue-specific roles of mitochondrial complex I and IV in adult mouse liver, finding that complex I loss is tolerated while complex IV dysfunction causes metabolic and functional impairments.

This paper identifies GASA6 as a non-antibiotic selectable marker for plant transformation, demonstrating its effectiveness in tobacco through growth and regeneration on sugar-free media.

This study uses dual-lipid metabolomics to compare lipid compositions of MTB and MB and their effects on bovine alveolar macrophages, revealing distinct metabolic responses and colonization mechanisms.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

The paper develops a cell type-specific multiomics pipeline to analyze guard cells and mesophyll cells, revealing a kinase cascade involved in ABA-induced stomatal closure.

This study shows that Cystathionine-β-synthase (CBS) maintains AKT-induced senescence and suppresses gastric cancer growth in PI3K/AKT-activated cells.

This study establishes three clinical breakpoint values for danofloxacin against Glaesserella parasuis using epidemiological, pharmacodynamic, and clinical data.

This study shows TMPRSS2 is a tumor suppressor in lung adenocarcinoma, with its downregulation linked to enhanced antitumor immunity and better response to immunotherapy.

The paper investigates how changes in action potential waveform contribute to excitation-contraction coupling failure during depolarization, identifying the integral of AP voltage over time as a key factor.

This study analyzes 3'UTRs of insect flaviviruses to identify novel xrRNAs involved in sfRNA biogenesis and provides insights into flavivirus evolution.

This study identifies genetic mutations in Zymomonas mobilis that cause self-flocculation by disrupting gene function and increasing c-di-GMP levels, enabling improved biomass recovery and productivity.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

This study shows MKP-1 modulates TRAF6 ligase activity by regulating DUBs, leading to altered ubiquitination and phosphorylation in TLR signaling.

This study reports the cryo-EM structure of PTH2R bound to TIP39 and a Gs protein, revealing ligand specificity and disease-associated mutation effects.