X. Wang

This study identifies impaired SR Ca2+ signaling and disrupted ion channel activity in Col4a1 mutant mice as contributors to age-related cerebral small vessel disease.

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

The paper uses single-cell RNA-seq to analyze factors influencing CD4 T cell activation and identifies distinct functional states and differentiation patterns.

This study shows that LRRK2 binds and remodels lipid membranes, suggesting its role in membrane dynamics and signaling.

This study uses ancient DNA to show that interstadial periods, not the Last Glacial Maximum, were the main driver of common vole population dynamics during the last glacial period.

The paper introduces siEVPRA, a method to detect proteins, mRNAs, and miRNAs in single EVs using fluorescence microscopy, showing high sensitivity and clinical utility in GBM samples.

The paper develops a proteomic pipeline to analyze ECM remodeling in lung squamous cell carcinoma, identifying 529 differentially expressed proteins and potential biomarkers.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

This paper identifies FAK-SFK signaling as a mechanism linking ECM rigidity sensing and ERBB2 activation to YAP-driven invasive growth and metastasis in HER2+ breast cancer.

This study shows that reducing SURF4 in the liver decreases PCSK9 and increases LDLR, leading to lower plasma cholesterol despite reduced lipoprotein secretion.

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

This study identifies NOTUM as a therapeutic target in advanced colorectal cancer, showing that its inhibition effectively arrests tumor growth and metastasis in models with APC and P53 mutations.

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

This study analyzes fecal metagenomes to identify viral signatures associated with colorectal cancer and adenoma, finding distinct virome patterns and developing predictive models with high accuracy.

This study shows gibberellins regulate stem cell fate in vascular cambium by modulating auxin transport, affecting xylem and phloem differentiation.

This paper develops amidase-dependent pyrazinoic acid prodrugs that bypass PncA activation, showing efficacy against PZA-resistant Mtb.

This study shows that Borrelia burgdorferi is polyploid in culture and ticks, with regular genome copy spacing controlled by ParA/ParZ and ParB/SMC systems.

This paper develops a method using chiral derivatization and TIMS-MS to separate and visualize 19 pairs of chiral amino acids in complex biological samples.

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

The paper reports the first crystal structure of a coronavirus M protein from batCOV5 and identifies its interaction with the N protein.

This study identifies OsAIM1 as essential for high basal SA levels in rice, which regulate stomatal aperture and shoot temperature.

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

This study investigates microbiome and short-chain fatty acids (SCFAs) profiles in rumen simulation technique (RUSITEC) systems inoculated with goat and cow rumen contents, identifying copresent microbial genomes associated with substrate degradation.

This study investigates the effects of FABP1 and FAS overexpression on collagen III and cross-linking in Zongdihua pig tissues, identifying their roles in fat deposition.

The paper identifies incomplete lineage sorting in Sulfitobacter, a marine bacterium, showing rapid speciation driven by ancestral polymorphism retention rather than adaptive selection.

This study identifies two switchable Rac1 pools in Drosophila border cells that integrate direction and coordination during collective migration.

The paper presents crystal structures of SALL family proteins bound to AT-rich DNA, revealing their recognition mechanism and functional importance in cell fate control.