X. Wang

This study shows lysine acetylation in E. coli inhibits translation by disrupting ribosome subunit association, linking metabolic state to protein synthesis.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This study investigates the molecular mechanisms of murine GBP2, revealing its lipid-binding affinity and dynamic behavior on membranes, which may contribute to membrane destruction.

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

FebRNA predicts RNA 3D structures using a fragment-ensemble-based approach, achieving reliable results for complex RNA topologies.

This study identifies a chitin-binding protein, CgCBP, highly expressed in the outer fold of the mantle of Pacific oyster Crassostrea gigas, which is linked to shell pigmentation through its role in periostracum structure.

The paper identifies new alleles of the tomato SELF PRUNING gene that alter plant compactness and yield, with sp-5732 increasing yield by up to 42%.

This study shows that interfering with DicVg4 and DicVgR genes in Diaphorina citri reduces vitellogenin accumulation, prevents normal egg formation, and leads to abnormal eggs and nymphs.

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

This study investigates the structural and biochemical features of Omicron BA.1 and BA.2 variants, showing increased infectivity and mouse ACE2 binding compared to wildtype, suggesting a potential human-cat-mouse-human transmission cycle.

This study identifies the role of renal macrophages in clearing intratubular particles and preventing kidney stone formation through phagocytosis and transmigration.

This study investigates how CaSR mutations cause different disease outcomes by showing that heterodimers reduce WT affinity and rescue mutant trafficking, while homodimers fail to function.

This study quantifies neoantigen-mediated immunoediting stages in cancer evolution across tumor types, showing elimination and escape signals predict immunotherapy response.

This paper introduces a method to chronically image blood microcirculation using liver-secreted fluorescent proteins, enabling long-term observation of vascular functions in mice.

This study compares antibody neutralization efficacy against SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, BA.2, and BA.3, showing increased resistance and the benefit of vaccine boosters.

This study shows that knocking out the Angiotensin II Type 1a Receptor in rats reduces high-fat diet-induced obesity by enhancing adipose lipolysis through the cAMP/PKA pathway.

The paper identifies resR as a target of positive selection in Mtb clinical isolates, linking its mutations to antibiotic resilience and treatment failure.

This study identifies sustained molecular signatures in monocytes and regulatory T cells in convalescent COVID-19 patients, associated with disease severity.

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

This study shows that CCR1 activation on respiratory epithelial cells suppresses RSV replication via Gi-mediated inhibition of STAT3 phosphorylation and HSP90 activity, independent of IFN-I.

This study improves plant growth-promotion by engineering specialized bacterial mutants within a single species and assembling them into consortia that enhance root colonization and disease resistance.

This study shows that high salinity activates CEF and reduces state transitions in three Chlamydomonas species, with psychrophilic species showing the highest CEF rates.

The paper introduces cgRNASP, a series of coarse-grained statistical potentials for RNA 3D structure evaluation, showing comparable or better performance than all-atom methods with higher efficiency.

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

This study identifies 4-vinylanisole as an aggregation pheromone that promotes sexual maturation synchrony in gregarious female locusts through a juvenile hormone/vitellogenin pathway.

This study identifies TFAM-dependent mitochondrial integrity in Tregs as critical for preserving immune homeostasis and preventing inflammaging.

This study identifies alnustone as a drug that inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A, reducing biofilm formation and protecting against infection.

This study identifies critical ecological protection areas in Aksu City and Wensu County by simulating human activity impacts and analyzing resistance surfaces across different scenarios.

This study uses TnSeq to identify genes required for swarming motility in Bacillus subtilis, finding known flagellar genes, previously reported regulators, and 36 additional genes that enhance swarming.