X. Xu

The paper examines how plot diversity affects the metabolome of leaves, roots, and root exudates in four subtropical tree species, finding stronger effects on leaves than roots or exudates.

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

The paper reports cryoEM structures of DNA-PKcs in inactive and activated forms, revealing structural changes in HEAT repeats that drive kinase activation.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study identifies two efficient multiplex genome editing tools for Phalaenopsis orchids using a protoplast platform, with DPII-Cpf1 showing the highest editing efficiency.

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

This study examines life-history fitness in F1 hybrids of Daphnia pulex and D. pulicaria, finding heterosis in four out of five traits, suggesting no major genetic incompatibilities and early speciation stage.

The paper measures nuclear stiffness in native tissues and finds that matrix disruption reduces both tissue and nuclear stiffness.

This paper introduces a method using high-pressure NMR spectroscopy to identify proteins with internal ligand-binding voids by detecting nonlinear chemical shift changes in 1H/15N HSQC experiments.

The paper shows that Cdc42 activity is crucial for the interaction between the cAMP/PKA pathway and CatSper function in sperm, affecting Ca2+ transport and fertilization.

The paper uses all-atom simulations to study protein condensates, revealing structural and dynamic details of phase separation in two IDPs and showing agreement with experiments.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

The paper uses high-pressure NMR to study conformational changes in ARNT PAS-B Y456T, finding that the slipped conformation is smaller and less compressible than the wildtype and involves an unfolded intermediate.

The study tracks vagino-cervical microbiome changes in 60 women over a year after oral probiotics, finding no colonization but stability in Lactobacillus-dominated communities and potential benefits for some individuals.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This study develops a novel preclinical model to assess long-term effects of precision radiation on salivary function and tissue integrity in mice.

The paper shows HetL provides immunity to HetR against PatS inhibition, enabling heterocyst differentiation in Nostoc PCC 7120 under nitrogen starvation.

This paper develops a CRISPR-based DNA detection method (CADD) that rapidly and specifically detects DNA from bacteria, cancer cells, and viruses in 30 minutes at room temperature.

The paper identifies and analyzes MATE transporter genes in wild chickpea species under aluminum stress, finding that CaMATE2 is upregulated in all lines while CaMATE1 is upregulated in most, correlating with root growth responses.

The paper uses a two-step molecular approach to delimit species in the spider genus Heptathela, identifying 20 putative species from 180 sampled individuals.

This study shows that CAPRI enables human neutrophils to chemotax through a broader range of chemoattractant gradients by controlling Ras adaptation and sensitivity.

This study shows that Salmonella Enteritidis effector AvrA suppresses autophagy by reducing Beclin-1 protein via the JNK pathway, promoting bacterial survival in host cells.

The paper uses phylogenetic analysis and ancestral state reconstruction to estimate flight potential in early birds and their relatives, finding that powered flight potential emerged multiple times from ancestors with high potential.

The paper investigates how HetR controls gene expression from DIF1 motif promoters during heterocyst differentiation, showing dependence on HetZ and modulation by PatU3.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

The paper identifies RASSF proteins as effectors linking RAS GTPases to the Hippo pathway, showing specificity in binding and regulatory roles.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.