Y. Gao

The paper shows that egg-surface bacteria in Bactrocera dorsalis increase β-caryophyllene in fruits, deterring oviposition by conspecific flies.

This study shows that immunization with SARS-CoV-2 RBD elicits potent neutralizing antibodies without antibody-dependent enhancement in rodents.

The paper analyzes urine proteome changes in α-synuclein transgenic mice to identify proteins associated with Parkinson's disease progression.

The paper identifies differential proteins in urine of tumor-bearing mice, showing early biomarker potential for melanoma and prostate cancer.

The paper reports a cryoEM structure of the PDE6 complex with GTP-bound transducin, revealing its catalytic mechanism and conformational dynamics.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This study compares global chemical modifications in human plasma proteomes between young and old age groups, identifying four significant differences in modifications such as succinylation, phosphorylation, and carbamylation.

This paper uses solid-state NMR to show that 150 kDa Aβ(1-42) oligomers contain both parallel and antiparallel β-sheets with a unique inter-strand registry shift.

This study shows that deletion of RgsA in Pseudomonas aeruginosa reduces growth and oxidative stress resistance in both planktonic and biofilm states.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

This study shows that SepF protein rings in bacteria control septal thickness, with ring diameter correlating to septum thickness and manipulation of ring size altering septum thickness.

This study identifies new antigenic sites on GII.4 norovirus capsid protein through population genomics, linking specific residues to variant emergence and vaccine design.

The paper shows that EGFR tyrosine kinase inhibitors (TKIs) cause intracellular EGFR accumulation only in specific mutation-TKI combinations, which predicts clinical response in patients.

This study compares protein metabolism and regeneration in diaphragm and gastrocnemius muscles of hibernating and summer-active Daurian ground squirrels, finding distinct regulatory patterns contributing to hypertrophy and atrophy.

This study identifies urinary protein biomarkers for uveitis using DIA and PRM proteomics in an EAU rat model, finding 12 proteins significantly altered before clinical symptoms.

This paper investigates the biosynthesis of formycin A and pyrazofurin A, identifying key enzymes and pathways involved in their C-nucleoside scaffold construction.

This study investigates how AMPK activity and energy metabolism change in yak muscle during postmortem aging using AICAR and STO-609.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

This study evolves E. coli under acid stress and identifies genetic and expression changes that enhance acid tolerance.

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

This study identifies a novel O_SCPCAPLC_SCPCAP-serine exporter, SerE, and its positive regulator NCgl0581 in C. glutamicum, showing their roles in amino acid export and transcriptional regulation.

The paper analyzes urinary proteomic changes in a rat brain tumor model to identify early biomarkers of tumor progression and differences between tumor growth locations.

This study examines collateral pathway development and arteriogenesis in swine hindlimbs after arterial ligation, finding increased vessel diameters and distinct collateral patterns based on ligation protocol.

This study identifies early urine proteome changes in a bone cancer rat model, detecting significant protein alterations before CT-identified lesions.

This study shows urine proteome changes occur in rats with approximately ten tumor cells, indicating early cancer detection potential through urine analysis.

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

This study uses evolutionary game theory to identify optimal life cycles for multicellular evolution, finding that only eight life cycles maximize population growth rate.

This paper introduces QUAD, a method to quantify global protein stability in tissues, revealing tissue-specific stability patterns and age-related changes in brain protein stability.